PMID: 7992901Dec 1, 1994Paper

Clonidine and lidocaine inhibition of isoflurane-induced tachycardia in humans

Anesthesiology
S TanakaA Namiki

Abstract

A rapid increase in isoflurane concentration can induce tachycardia and hypertension and increase plasma catecholamine concentrations. To investigate a possible mechanism, we measured hemodynamic responses to isoflurane administered via mask; we also administered clonidine for premedication, lidocaine topically to the nasal mucosa, or lidocaine intravenously to evaluate the effect of these drugs on the hemodynamic responses. Forty ASA physical status 1 patients (aged 20-30 yr) scheduled for elective oral surgery participated in the study. Thirty patients were randomly allocated to one of three groups: a control group, a group receiving 3-4 micrograms.kg-1 of oral clonidine for premedication, and a group receiving 2 ml of 4% lidocaine spray to the nasal mucosa. Ten patients were assigned nonrandomly to a group receiving intravenous lidocaine continuously (0.4 mg.kg-1 bolus followed by 30 micrograms.kg-1.min-1) after the initial randomized experiments were done to test whether systemic lidocaine blunts the responses to inhaled isoflurane. Anesthesia was induced with thiamylal, after which inhalation of 1% isoflurane in 100% oxygen via mask was begun. The inspired concentration of isoflurane was increased by 1% every 5 min to a ma...Continue Reading

Citations

Mar 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K TakakuraY Goto
Nov 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M NakayamaA Namiki
Dec 13, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Masayasu NakayamaAkiyoshi Namiki
Mar 7, 2002·British Journal of Anaesthesia·O PickerJ O Arndt
May 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T KamibayashiM Maze
May 10, 2002·Journal of Cardiovascular Pharmacology and Therapeutics·Shengmei ZhouPeng-Sheng Chen
Mar 8, 2003·European Journal of Anaesthesiology·N AnzawaA Matsuki
Mar 8, 2003·European Journal of Anaesthesiology·R TytherG Shorten
Mar 8, 2003·European Journal of Anaesthesiology·C D HanningE K Perry
Mar 8, 2003·European Journal of Anaesthesiology·O A P SantanenM P J Paloheimo
Mar 8, 2003·European Journal of Anaesthesiology·H Erolçay, L Yüceyar
Mar 8, 2003·European Journal of Anaesthesiology·B HeindlB F Becker
Mar 8, 2003·European Journal of Anaesthesiology·M WestphalG Brodner
Mar 8, 2003·European Journal of Anaesthesiology·R BogdanskiE Kochs
Mar 8, 2003·European Journal of Anaesthesiology·T BouillonA Hoeft
Mar 8, 2003·European Journal of Anaesthesiology·K MikawaY Niwa
Mar 8, 2003·European Journal of Anaesthesiology·D HarmonD Lowe
Mar 8, 2003·European Journal of Anaesthesiology·J J LehotO Bastien
Mar 8, 2003·European Journal of Anaesthesiology·G KierzekJ L Pourriat
Jan 31, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Riikka LautamakiFrank M Bengel

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