PMID: 2224504Jul 2, 1990Paper

Clonidine and phenylephrine injected into the lateral hypothalamus inhibits water intake in rats

Brain Research
A C FerrariJ V Menani

Abstract

It has been demonstrated that peripheral or intracerebroventricular (i.c.v.) administration of the alpha 2-adrenoceptor agonist, clonidine, blocks the water intake induced by several dipsogenic stimuli in rats. In the present investigation we studied the effect of the injection of clonidine, phenylephrine, prazosin or yohimbine into the lateral hypothalamic area (LHA) on the water intake induced by water deprivation or central angiotensin II (AII) in rats. Rats with chronic cannulas implanted into the lateral ventricle and LHA were used. Injection of clonidine or phenylephrine into the LHA reduced the water intake produced by both water deprivation and i.c.v. injection of AII. Previous injection of the alpha 1- or alpha 2-adrenoceptor antagonists, prazosin or yohimbine, into the LHA reduced the antidipsogenic effect of clonidine or phenylephrine injected into the same area. These results suggest that the alpha 1- and alpha 2-adrenergic receptors of the hypothalamus are part of the central inhibitory system for the thirst produced by dehydration or central AII.

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Citations

Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·E ColombariJ V Menani
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Dec 4, 2003·Brain Research·Lisandra Brandino de OliveiraJosé Vanderlei Menani
Nov 12, 2002·Brain Research·Lisandra Oliveira MargathoJosé Vanderlei Menani
May 1, 1997·Pharmacology, Biochemistry, and Behavior·M M YadaL A de Luca Júnior
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·L A De LucaE W Meyer
May 14, 1999·Journal of the Autonomic Nervous System·R CecanhoL A De Luca
Jul 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Y ChenC Y Chai
Jan 1, 1997·Brain Research Bulletin·M M YadaL A De Luca
Jul 29, 1999·Brain Research Bulletin·J V MenaniL A De Luca
Feb 13, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C A F AndradeJ V Menani
Aug 22, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A M SugawaraL A De Luca
Apr 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L A De-Luca Júnior, J V Menani
Apr 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R L AlmeidaL A De Luca
Jul 31, 1998·The American Journal of Physiology·K S Butcher, D F Cechetto
Mar 28, 2009·European Journal of Pharmacology·Carina A F de AndradeJosé V Menani

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