Clonidine as an adjuvant for propranolol enhances its effect on infiltrative cutaneous analgesia in rats

Neuroscience Letters
Ching-Hsia HungYu-Wen Chen

Abstract

Clonidine prolongs duration of analgesia when used as an adjunct to local anesthetics for infiltrative cutaneous analgesia, and propranolol produces local anesthesia. The purpose of the experiment was to evaluate clonidine as an adjuvant for propranolol on the quality and duration of cutaneous analgesia. A rat model of cutaneous trunci muscle reflex (CTMR) in response to local skin pinprick was employed to evaluate the cutaneous analgesic effect of propranolol combined with clonidine. The long-lasting local anesthetic bupivacaine was used as control. Cutaneous analgesia elicited by propranolol and bupivacaine was dose-dependent, and both propranolol (9.0μmol) and bupivacaine (1.8μmol) produced 100% nociceptive blockade. On an 50% effective dose (ED50) basis, the relative potency was bupivacaine [0.48 (0.42-0.55) μmol] greater than propranolol [2.27 (1.98-2.54) μmol] (p<0.01). Subcutaneous saline and clonidine (0.12μmol) did not produce cutaneous analgesia. The mixture of an ineffective-dose clonidine (0.12μmol) and a drug (propranolol or bupivacaine) at ED50 or ED95 increased the potency and extended the duration at producing cutaneous analgesia. The resulting data demonstrated that propranolol is less potent than bupivacaine a...Continue Reading

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Citations

May 28, 2017·Neuroscience Letters·Yu-Wen ChenChing-Hsia Hung
May 31, 2018·Anesthesia and Analgesia·An-Kuo ChouChing-Hsia Hung
Oct 17, 2018·Pharmacological Reports : PR·An-Kuo ChouChing-Hsia Hung
May 17, 2019·Anesthesia and Analgesia·An-Kuo ChouChing-Hsia Hung
Apr 22, 2018·Pharmacological Reports : PR·Ching-Hsia HungYu-Wen Chen

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