Clonidine as an adjuvant to ropivacaine-induced supraclavicular brachial plexus block for upper limb surgeries

Journal of Anaesthesiology, Clinical Pharmacology
Kalyani Nilesh Patil, Noopur Dasmit Singh

Abstract

Ropivacaine is a new amide, long acting, pure S-enantiomer, local anesthetic, with differential blocking effect. The addition of clonidine to local anesthetic improves the quality of peripheral nerve blocks. This study was conducted to evaluate the effect of clonidine on characteristics of ropivacaine-induced supraclavicular brachial plexus block. A total of 60 adult patients were randomly recruited to two groups of 30 each: Group I: 30 ml 0.75% ropivacaine + 1 ml normal saline. Group II: 30 ml 0.75% ropivacaine + 1 mcg/kg clonidine diluted to 1 ml with normal saline. The onset of sensorimotor block was earlier in Group II (4.36 ± 0.81 min for sensory block and 9.83 ± 1.12 min for motor block) than in Group I (4.84 ± 0.65 min for sensory block and 10.85 ± 0.79 min for motor block). The duration of both sensory and motor block were significantly prolonged by clonidine (P < 0.001). The duration of analgesia was also prolonged in patients receiving clonidine (613.10 ± 51.797 min vs. 878.33 ± 89.955 min). Although incidence of hypotension and bradycardia was higher in Group II when compared to Group I, it was not clinically significant. Ropivacaine 0.75% is well-tolerated and provides effective surgical anesthesia as well as relief...Continue Reading

References

Oct 1, 1988·Acta Anaesthesiologica Scandinavica·B AkermanC Trossvik
Aug 1, 1997·Anesthesiology·J M Bernard, P Macaire
Feb 11, 2000·Acta Anaesthesiologica Scandinavica·W ErlacherS Kapral
Jul 11, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W ErlacherS Kapral
Apr 28, 2005·Expert Review of Neurotherapeutics·Tom G Hansen
Oct 5, 2006·Current Opinion in Anaesthesiology·J S Gabriel, V Gordin
Feb 22, 2007·Anesthesia and Analgesia·Giovanni Cucchiaro, Arjunan Ganesh
Jun 23, 2009·British Journal of Anaesthesia·A M El-HennawyS R Boulis
Jun 30, 2011·Indian Journal of Anaesthesia·Gaurav Kuthiala, Geeta Chaudhary

❮ Previous
Next ❯

Citations

May 10, 2016·Journal of Pain & Palliative Care Pharmacotherapy·Daryl S HenshawJonathan D Jaffe
Dec 2, 2017·Nigerian Journal of Clinical Practice·R Y Ateser, N Kayacan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.