Clonidine decreases vasoconstriction and shivering thresholds, without affecting the sweating threshold

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
G NicolaouG G Giesbrecht

Abstract

This study was conducted to test the hypothesis that clonidine produces a dose-dependent increase in the sweating threshold and dose-dependent decreases in vasoconstriction and shivering thresholds. Six healthy subjects (two female) were studied on four days after taking clonidine in oral doses of either 0 (control), 3, 6 or 9 micrograms.kg-1. The order followed a balanced design in a double-blind fashion. Oesophageal temperature and mean skin temperature (from 12 sites) were measured. Subjects were seated in 37 degrees C water which was gradually warmed until sweating occurred (sweat rate increased above 50 g.m-2.h-1). The water was then cooled gradually until thresholds for vasoconstriction (onset of sustained decrease in fingertip blood flow) and shivering (sustained elevation in metabolism) were determined. Thresholds were then referred to as the core temperature, adjusted to a designated mean skin temperature of 33 degrees C. High dose clonidine similarly decreased the adjusted core temperature thresholds for vasoconstriction by 1.16 +/- 0.30 degrees C and for shivering by 1.63 +/- 0.23 degrees C (P < 0.01). The dose response effects were linear for both cold responses with vasoconstriction and shivering thresholds decreas...Continue Reading

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Citations

Jan 14, 2009·Best Practice & Research. Clinical Anaesthesiology·Oliver Kimberger, Andrea Kurz
May 22, 2007·Journal of the Neurological Sciences·M Asim Mahmood, Richard M Zweifler
Dec 25, 2007·Pharmacotherapy·Paul A Arpino, David M Greer
Mar 7, 2002·British Journal of Anaesthesia·F Jin, F Chung
Oct 16, 1999·Anesthesiology·E P HornJ Schulte am Esch
Jun 11, 2009·Anesthesiology·Pekka O Talke
Dec 24, 2004·Anesthesia and Analgesia·Andrea ParisPeter H Tonner
Dec 24, 2004·Anesthesia and Analgesia·Claudia StapelfeldtPekka O Talke
Aug 28, 2021·International Journal of Environmental Research and Public Health·Simon RauchPeter Paal

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