Clonidine inhibits IgE-mediated and IgE-independent in vitro histamine release from human basophil leukocytes.

International Journal of Immunopharmacology
A MiadonnaC Zanussi

Abstract

Clonidine, a common antihypertensive agent, was recently shown to inhibit antigen-induced wheal and flare reactions, as well as allergen-evoked bronchoconstriction in allergic patients. In this study we investigated the in vitro anti-allergic properties of clonidine. This alpha 2 adrenoceptor agonist inhibited, in a dose-dependent fashion, basophil histamine secretion elicited by anti-IgE and f-met peptide; it also blocked, though to a lesser extent, the calcium ionophore A23187-induced histamine release. H2 receptor stimulation seems to be responsible for the reduction in histamine release observed, since it can be antagonized by cimetidine, but not by alpha 1, alpha 2 and H1 blockers.

References

Jul 22, 1976·Nature·Y AudigierJ Schwartz
Jun 1, 1987·The Journal of Allergy and Clinical Immunology·B R LindgrenR G Andersson
Jul 27, 1973·Nature·L M Lichtenstein, E Gillespie
Aug 24, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·H O Karppanen, E Westermann

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Citations

Sep 1, 2015·Frontiers in Pharmacology·Angela Scanzano, Marco Cosentino
Apr 17, 2014·Multidisciplinary Respiratory Medicine·Gennaro D'AmatoMaria D'Amato

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