PMID: 3768767Sep 1, 1986Paper

Clonidine prolongs canine tetracaine spinal anaesthesia

Canadian Anaesthetists' Society Journal
M D BedderW R Pucci

Abstract

Using a randomized blind cross-over design, the comparative efficacy of clonidine in prolonging tetracaine spinal anaesthesia was studied in six mongrel dogs. Lumbar subarachnoid injections (1 ml) of: tetracaine 4 mg with clonidine 150 micrograms, tetracaine 4 mg with epinephrine 200 micrograms, tetracaine 4 mg, clonidine 150 micrograms, epinephrine 200 micrograms, and five per cent dextrose in H2O (vehicle) were administered randomly to each animal at 5-7 day intervals. Subarachnoid tetracaine produced a motor blockade of 186 +/- 58 (mean +/- SEM) min. Both clonidine and epinephrine produced a similar prolongation of tetracaine motor blockade, 135 per cent (p less than 0.01) and 116 per cent (p less than 0.05) respectively, compared with tetracaine alone. No motor blockade was observed in dogs receiving clonidine, epinephrine or five per cent dextrose in H2O. The addition of clonidine to tetracaine spinal anaesthesia produced a significant increase in duration of sensory blockade, 56 per cent (p less than 0.01) and 107 per cent (p less than 0.01) respectively, when compared to tetracaine with and without epinephrine. Subarachnoid clonidine alone produced a sensory blockade of 76 +/- 17 minutes, while only one animal receiving ...Continue Reading

References

Jan 1, 1985·Canadian Anaesthetists' Society Journal·R KozodyM O Cumming
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Jan 25, 1980·European Journal of Pharmacology·F P ZemlanD W Pfaff
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Citations

Nov 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R Kozody
Nov 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F GotoT Fujita
Mar 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F GotoT Fujita
Oct 1, 1992·Acta Anaesthesiologica Scandinavica·O BoicoJ X Mazoit
Dec 1, 1995·The Journal of Pharmacy and Pharmacology·L AttoliniB Bruguerolle
Jul 23, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Ahmed ShafikIsmail Shafik
Apr 1, 1995·Annals of Medicine·N Rawal
Apr 1, 2002·Veterinary Anaesthesia and Analgesia·Tamara L GrubbL Dean Lamb

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