Clonidine suppression of bradycardia induced by gigantocellular reticular nucleus in the cat

European Journal of Pharmacology
J S Kuo, S H Chan

Abstract

In chloralose-urethane-anesthetized cats, intravertebral injection of clonidine (0.5--4.0 micrograms/kg) elicited a drastic suppression of the bradycardia induced by stimulating the gigantocellular reticular nucleus (GRN). The degree of blockage of GRN-induced cardioinhibtion was related to the time course of the inherent cardiovascular effects of clonidine. It was also dependent upon the dose of the imidazoline compound and the intensity/train pulse frequency of reticular stimulation. It was suggested that the two mechanisms may interact with one another in the brainstem and possible modes of interaction were discussed.

References

Aug 1, 1976·European Journal of Pharmacology·M LaubieM Drouillat
Aug 1, 1972·European Journal of Pharmacology·W Kobinger, A Walland
Oct 1, 1973·European Journal of Pharmacology·A Scriabine, J M Stavorski

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