Clonidine treatment for agitation in children after sevoflurane anesthesia

Anesthesia and Analgesia
Simonetta TesoroVito Aldo Peduto

Abstract

Clonidine is effective in treating sevoflurane-induced postanesthesia agitation in children. We conducted a study on 169 children to quantify the risk reduction of clonidine agitation in patients admitted to our day-surgery pediatric clinic. Children were randomly allocated to receive clonidine 2 mug/kg or placebo before general anesthesia with sevoflurane that was also supplemented with a regional or central block. An observer blinded to the anesthetic technique assessed recovery variables and the presence of agitation. Pain and discomfort scores were significantly decreased in the clonidine group; the incidence of agitation was reduced by 57% (P = 0.029) and the incidence of severe agitation by 67% (P = 0.064). Relative risks for developing agitation and severe agitation were 0.43 (95% confidence interval, 0.24-0.78) and 0.32 (0.09-1.17), respectively. Clonidine produces a substantial reduction in the risk of postsevoflurane agitation in children.

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Citations

Dec 7, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Robin G Cox
Feb 1, 2013·Journal of the American Veterinary Medical Association·Kerry J WoodhouseLarry D Galuppo
Feb 5, 2014·Anesthesiology Clinics·Richard J Banchs, Jerrold Lerman
Feb 12, 2013·Journal of Pediatric Ophthalmology and Strabismus·Laura J HeinmillerAdam R Thode
Jan 31, 2008·Paediatric Anaesthesia·Anja Pohl-SchickingerBrigitte Stiller
Jul 6, 2011·Paediatric Anaesthesia·Stephanie MalarbiAndrew Davidson
Oct 21, 2016·Anesthesiology and Pain Medicine·Faramarz MosaffaGholam Reza Mohseni
Oct 4, 2014·Paediatric Anaesthesia·Stefan Lundeberg
Feb 14, 2015·International Journal of Pediatric Otorhinolaryngology·E EricssonS Lundeberg
Jan 29, 2014·The Cochrane Database of Systematic Reviews·Paul LambertPhilippa Middleton
Mar 21, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Santiago MencíaJesús López-Herce
Sep 13, 2014·The Cochrane Database of Systematic Reviews·David CostiPhilippa Middleton
Jul 11, 2006·Current Opinion in Anaesthesiology·Arthur W Wallace
Nov 10, 2006·Current Opinion in Anaesthesiology·Per-Arne Lonnqvist, Neil S Morton
Dec 21, 2006·Anesthesia and Analgesia·Gordana P Vlajkovic, Radomir P Sindjelic
May 5, 2007·Current Opinion in Anaesthesiology·Jerrold Lerman
Dec 22, 2007·Paediatric Anaesthesia·Michael J Stella, Ann G Bailey
Nov 29, 2007·Anesthesiology·Yutaka YasuiFusao Kato
Jul 8, 2011·Current Opinion in Anaesthesiology·Ian Smith
May 3, 2019·Current Opinion in Anaesthesiology·Arash Afshari
Apr 10, 2020·The Cochrane Database of Systematic Reviews·Olga RomantsikMatteo Bruschettini
Nov 1, 2016·Paediatric Drugs·Arthura D Moore, Doralina L Anghelescu

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