Clonidine treatment for agitation in children after sevoflurane anesthesia

Anesthesia and Analgesia
Simonetta TesoroVito Aldo Peduto


Clonidine is effective in treating sevoflurane-induced postanesthesia agitation in children. We conducted a study on 169 children to quantify the risk reduction of clonidine agitation in patients admitted to our day-surgery pediatric clinic. Children were randomly allocated to receive clonidine 2 mug/kg or placebo before general anesthesia with sevoflurane that was also supplemented with a regional or central block. An observer blinded to the anesthetic technique assessed recovery variables and the presence of agitation. Pain and discomfort scores were significantly decreased in the clonidine group; the incidence of agitation was reduced by 57% (P = 0.029) and the incidence of severe agitation by 67% (P = 0.064). Relative risks for developing agitation and severe agitation were 0.43 (95% confidence interval, 0.24-0.78) and 0.32 (0.09-1.17), respectively. Clonidine produces a substantial reduction in the risk of postsevoflurane agitation in children.


Jul 20, 1999·Paediatric Anaesthesia·S L LapinA M Reynolds
Aug 18, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H ViitanenA Yli-Hankala
Aug 29, 2000·Anesthesia and Analgesia·S UezonoS Morita
Jun 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N AnzawaA Matsuki
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Carolyn A FairbanksGeorge L Wilcox
May 23, 2003·Anesthesia and Analgesia·Terri Voepel-LewisAlan R Tait
Jun 15, 2004·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Renee C B ManworrenRodica Pop

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