Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome

Nature Genetics
E V SeminaJ C Murray

Abstract

Rieger syndrome (RIEG) is an autosomal-dominant human disorder that includes anomalies of the anterior chamber of the eye, dental hypoplasia and a protuberant umbilicus. We report the human cDNA and genomic characterization of a new homeobox gene, RIEG, causing this disorder. Six mutations in RIEG were found in individuals with the disorder. The cDNA sequence of Rieg, the murine homologue of RIEG, has also been isolated and shows strong homology with the human sequence. In mouse embryos Rieg mRNA localized in the periocular mesenchyme, maxillary and mandibular epithelia, and umbilicus, all consistent with RIEG abnormalities. The gene is also expressed in Rathke's pouch, vitelline vessels and the limb mesenchyme. RIEG characterization provides opportunities for understanding ocular, dental and umbilical development and the pleiotropic interactions of pituitary and limb morphogenesis.

References

Feb 1, 1978·Journal of Medical Genetics·N Fitch, M Kaback
Sep 1, 1992·Human Molecular Genetics·B J PadanilamJ C Murray
Mar 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J TreismanC Desplan
Jan 1, 1991·Methods in Cell Biology·R M Harland
Mar 5, 1987·Nature·G E MooreO Jensson
Dec 1, 1969·Plastic and Reconstructive Surgery·S M Alhady, K Sivanantharajah
Jul 1, 1967·The British Journal of Ophthalmology·R A Crawford
Dec 1, 1995·Nature Genetics·G ProetzelT Doetschman
Apr 21, 1995·Cell·C A Beelman, R Parker
Feb 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D M Juriloff, D G Mah
Apr 1, 1995·Nature Genetics·F S Collins
Jan 1, 1993·Methods in Enzymology·D Sassoon, N Rosenthal
Jul 29, 1994·Cell·R Krumlauf
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·M MuenkeM S Lubinsky
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A Asson-BatresG C Bagby
Jan 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M MehrabianA J Lusis
Feb 1, 1996·Nature Genetics·R M Winter
Mar 1, 1996·Nature Genetics·M A BedellN G Copeland

❮ Previous
Next ❯

Citations

Jun 1, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M A McCollum, P T Sharpe
Apr 26, 2001·Cell Biology International·L F NicholsonM Goulding
Feb 7, 2012·Pediatric Cardiology·Hongbing LiuYiping Chen
Jun 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J FavorD Stambolian
Jan 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M J CrawfordJ Drouin
May 10, 2006·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·P Dressler, E Gramer
Aug 10, 2004·Cell and Tissue Research·Marten P SmidtJ Peter H Burbach
Jun 6, 2013·Biochemical Genetics·Takehiko ShimizuTakahide Maeda
Jan 12, 2011·Breast Cancer Research and Treatment·Georg GöbelGünter Daxenbichler
Jul 18, 2012·Molecular and Cellular Biochemistry·Haihua WangBo Yan
Jul 20, 2007·Pituitary·Clement C Cheung, Robert H Lustig
Sep 10, 2005·Reviews in Endocrine & Metabolic Disorders·Karine Rizzoti, Robin Lovell-Badge
Aug 21, 2008·Current Neurology and Neuroscience Reports·Mark Borchert, Pamela Garcia-Filion
Nov 6, 2010·Biomolecular NMR Assignments·Thomas DoerdelmannMark Rance
Nov 19, 2003·European Journal of Pharmacology·Marten P SmidtJ Peter H Burbach
Apr 21, 2005·Seminars in Cell & Developmental Biology·Filippo Del Bene, Joachim Wittbrodt
Mar 5, 2004·Survey of Ophthalmology·Ian M MacDonaldMaria A Musarella
Sep 27, 2000·American Journal of Ophthalmology·W L Alward
Jan 23, 1998·American Journal of Ophthalmology·W L AlwardJ C Murray
Jul 18, 2002·Annales de génétique·Liesbeth J J M Maillette de Buy Wenniger-Prick, Raoul C M Hennekam
Dec 31, 2002·Survey of Ophthalmology·John H FingertWallace L M Alward
Sep 28, 1998·Brain Research. Developmental Brain Research·C LindbergD B Jacoby
Jul 24, 1998·Trends in Genetics : TIG·D E Watkins-Chow, S A Camper
Mar 31, 1999·Trends in Genetics : TIG·H Peters, R Balling
Nov 28, 2002·Biochimie·Ahmet CivasSébastien Navarro
Dec 12, 2001·Molecular and Cellular Endocrinology·P E Mullis
Aug 29, 1998·Molecular and Cellular Endocrinology·J DrouinJ J Tremblay
Feb 1, 2003·Mechanisms of Development·Antje BrouwerFrits Meijlink
Dec 22, 1999·Current Opinion in Cell Biology·J S Dasen, M G Rosenfeld
May 29, 2000·Current Opinion in Genetics & Development·B Casey, B P Hackett
Feb 7, 2001·Trends in Endocrinology and Metabolism : TEM·L E CohenF E Wondisford
Oct 8, 1999·Trends in Endocrinology and Metabolism : TEM·H L BurrowsS A Camper
Feb 17, 2000·Trends in Endocrinology and Metabolism : TEM·A López-BermejoR G Rosenfeld
May 7, 2003·Trends in Cardiovascular Medicine·Diego Franco, Marina Campione
Nov 5, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J S Parks, M R Brown
Feb 26, 2000·Molecular Medicine Today·I Capdevila, J C Izpisúa Belmonte

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.