Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)

Cytogenetics and Cell Genetics
T ShiratsuchiT Tokino

Abstract

We have identified two novel human genes homologous to BAI1 (brain-specific angiogenesis inhibitor 1), an angiogenesis inhibitor that is a candidate for involvement in development of glioblastoma. Like BAI1, these two genes, designated BAI2 and BAI3, were specifically expressed in brain, and are likely to be expressed in the same type of cells. However, in spite of similar tissue specificity among the three BAI genes, only BAI1 is transcriptionally regulated by p53. BAI3 expression was absent in two of nine glioblastoma cell lines examined and was significantly reduced in three of the remaining seven. These data suggest that members of this novel gene family may play important roles in suppression of glioblastoma. BAI1, BAI2 and BAI3 were mapped to 8q24, 1p35 and 6q12, respectively.

Citations

Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·W V ZhangN S Stott
Nov 27, 2010·The Journal of Physiological Sciences : JPS·Daisuke OkajimaHiroshi Yokota
Jun 6, 2000·Trends in Biochemical Sciences·M StaceyA J McKnight
Jan 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marc F BolligerThomas C Südhof
Dec 15, 2010·Bioinformatics·Vinicius BonatoKim-Anh Do
Jul 17, 2008·Schizophrenia Bulletin·Pamela DeRosseAnil K Malhotra
Sep 16, 2004·Molecular and Cellular Biology·Ben DaviesUlrich Gottwald
Aug 25, 2001·Annual Review of Neuroscience·T C Südhof
Apr 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joseph G DumanKimberley F Tolias
Mar 20, 2014·Trends in Pharmacological Sciences·Jason R StephensonRandy A Hall
Apr 22, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sarah M Cork, Erwin G Van Meir
Apr 7, 2010·Journal of Receptor and Signal Transduction Research·Daisuke OkajimaHiroshi Yokota
Nov 16, 2013·Cell Communication & Adhesion·Julia Simundza, Pamela Cowin
Feb 18, 2016·Neural Plasticity·Joseph G DumanKimberley F Tolias
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Timothy B RappHoward A Chansky
Dec 26, 2006·Colloids and Surfaces. B, Biointerfaces·Kun-Xian ShuLi-Xiang Wu
May 20, 2008·Genomics·Austin L HughesMeredith Yeager
Sep 10, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hae Jin KeeKyung Keun Kim
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Frank K ReiherSteven C Campbell
Sep 14, 2004·Oncogene·Yoshio AnazawaYusuke Nakamura
Apr 3, 2008·Nature Reviews. Drug Discovery·Malin C Lagerström, Helgi B Schiöth
Jul 30, 2010·Nature·Zhengyan KanSomasekar Seshagiri
Dec 25, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ariel F MartinezMauricio Arcos-Burgos
May 4, 2013·Nature Reviews. Cancer·Morgan O'HayreJ Silvio Gutkind
Sep 20, 2000·Journal of Receptor and Signal Transduction Research·J S Hayflick
Oct 3, 2017·Annual Review of Pharmacology and Toxicology·Ryan H Purcell, Randy A Hall

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