PMID: 9420328Feb 21, 1998Paper

Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor

Genes & Development
Chiaki HidaiThomas Quertermous

Abstract

We have taken advantage of an enhancer trap event in a line of transgenic mice to identify a unique developmentally regulated endothelial cell locus (Del1). The protein encoded in this locus contains three EGF-like repeats homologous to those in Notch and related proteins, including an EGF-like repeat that contains an RGD motif, and two discoidin I-like domains. Del1 is shown to be a matrix protein and to promote adhesion of endothelial cells through interaction with the alphavbeta3 integrin receptor. Embryonic endothelial-like yolk sac cells expressing recombinant Del1 protein, or grown on an extracellular matrix containing Del1 protein, are inhibited from forming vascular-like structures. Expression of Del1 protein in the chick chorioallantoic membrane leads to loss of vascular integrity and promotes vessel remodeling. Del1 is thus a new ligand for the alphavbeta3 integrin receptor and may function to regulate vascular morphogenesis or remodeling in embryonic development.

References

Jan 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C J DrakeC D Little
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W MatthewsI R Lemischka
Dec 1, 1991·The American Journal of Anatomy·B J TripathiN S Borisuth
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A J BucklerD E Housman
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J D StubbsG Parry
Oct 1, 1989·The American Review of Respiratory Disease·D M Noden
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C J O'Kane, W J Gehring
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R J JennyK G Mann
Jan 1, 1987·Differentiation; Research in Biological Diversity·R HallmannW Risau
Jul 5, 1985·Journal of Molecular Biology·G von Heijne
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B M PeaultN M Le Douarin
Dec 5, 1981·Journal of Molecular Biology·S PooleW Rowekamp
Apr 22, 1994·Science·P C BrooksD A Cheresh
Apr 14, 1995·Science·S Artavanis-TsakonasM E Fortini
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T N SatoK L Audus
Jun 1, 1996·Nature Medicine·M S O'ReillyJ Folkman

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Citations

Sep 25, 2001·The Journal of Pathology·F V Peale, M E Gerritsen
Jul 31, 1998·Protein Science : a Publication of the Protein Society·S BaumgartnerP Bucher
Aug 19, 2007·Cell and Tissue Research·Chiaki HidaiShinichiro Kokubun
Mar 7, 2008·Molecular Biotechnology·Hisataka KitanoShinichiro Kokubun
Jun 21, 2005·Biochemical and Biophysical Research Communications·Masato AokiTomoatsu Kimura
Oct 9, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Albert J Sinusas
Mar 5, 2004·Survey of Ophthalmology·Avinash TantriLarry A Donoso
Oct 6, 1999·Current Opinion in Cell Biology·G BazzoniM G Lampugnani
Nov 24, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·F VellaG J Arlaud
Apr 19, 2005·Nature Medicine·Jean-Sébastien SilvestreZiad Mallat
Jun 2, 2005·Nature Reviews. Cancer·Dario Neri, Roy Bicknell
Feb 13, 2001·Molecular Biology of the Cell·M GonzalesJ C Jones
Jul 12, 2011·Cardiovascular Research·Paul D Williams, Paul A Kingston
May 19, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas SchürpfJia-Huai Wang
Jan 15, 2014·Clinical & Developmental Immunology·Jieun ShinGeorge Hajishengallis
Aug 5, 2009·Thrombosis and Haemostasis·Emmanouil ChavakisTriantafyllos Chavakis
Jan 24, 2003·American Journal of Respiratory Cell and Molecular Biology·Daniel J TschumperlinJeffrey M Drazen
Jan 18, 2013·BMC Gastroenterology·Jan G D'HaeseGüralp O Ceyhan
Mar 23, 2013·Orphanet Journal of Rare Diseases·Tara K SigdelGary K Steinberg
Sep 22, 2010·World Journal of Gastroenterology : WJG·Jian-Cong SunJian-Chuan Xia
Jan 22, 2014·Nutrients·Miguel Ángel Medina, Ana R Quesada
Aug 14, 2001·Biochemical and Biophysical Research Communications·B E PfisterT M Schmid
Oct 22, 2013·Tissue Engineering. Part a·Ema C CiucurelMichael V Sefton
Jul 10, 2002·The Journal of Cell Biology·Susan S Smyth, Cam Patterson
May 6, 2015·International Journal of Molecular Medicine·Monowar AzizPing Wang
Oct 2, 2015·Science Translational Medicine·Jieun ShinGeorge Hajishengallis
Nov 18, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·George P YangMichael T Longaker
Jul 25, 2015·Experimental & Molecular Medicine·Jaehun LeeJong-Hoon Kim
Jul 4, 2003·The Journal of Clinical Investigation·Jingping ZhongJudith A Varner
Feb 7, 2013·Blood·Iva NikolicMirko H H Schmidt

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