Cloning and characterization of FAM13A1--a gene near a milk protein QTL on BTA6: evidence for population-wide linkage disequilibrium in Israeli Holsteins

Genomics
Miri CohenEyal Seroussi

Abstract

A cluster of genes coding for proteins of the extracellular matrix (ECM) containing sequence motifs essential for integrin-receptor interactions is located on HSA4q21 and on BTA6, within the critical region of a quantitative trait locus (QTL) affecting milk protein production. Genes within this cluster are involved in the formation of bone and lobuloalveolar structures in mammary gland and in kidney function. We cloned a bovine gene neighboring this ECM cluster, termed FAM13A1, the first member of a novel gene family (FAM13). A short predominant 5.1-kb mRNA variant capable of encoding 697 amino acids is transcribed from 18-exon orthologous genes in human and mouse. All putative protein orthologs contained a bipartite nuclear-localization signal and two coil-coiled domains. We detected two other FAM13 paralogs, C5ORF5 and FAM13C1, on HSA5q31 and HSA10q21, respectively. All FAM13 paralogs produce transcripts that are complementary to adjacent genes, suggesting that antisense transcription may regulate their functions. The structure of a longer 5.9-kb variant, FAM13A1_v2, that has an extra 7-exon putative RhoGAP domain at the N-terminus provides further clues to FAM13 function. Analysis of 400 bulls revealed a population-wide link...Continue Reading

Citations

May 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Robert D SchnabelJeremy F Taylor
Oct 24, 2012·EMBO Molecular Medicine·Annerose BerndtSteven D Shapiro
Feb 23, 2010·Nature Genetics·Michael H ChoEdwin K Silverman
Jan 1, 2012·BoneKEy Reports·David Karasik, Miri Cohen-Zinder
Jun 19, 2012·Clinical Epigenetics·Robert TellRichard V Benya
May 17, 2011·Journal of Neuroimmunology·Sangmin LeeMichael C Levin
Aug 1, 2006·Social Science & Medicine·Barbara Prainsack, Tim D Spector
Oct 27, 2011·Biochemical and Biophysical Research Communications·Yi GuoHao Deng
Nov 8, 2006·BMC Veterinary Research·Madhu S TantiaMonika Sodhi
Aug 28, 2015·Scientific Reports·Iwona Ziółkowska-SuchanekJerzy Nowak
Jun 17, 2011·Cambridge Quarterly of Healthcare Ethics : CQ : the International Journal of Healthcare Ethics Committees·Sarah Chan, John Harris
Jan 4, 2019·Molecular Genetics & Genomic Medicine·Yingai ZhangHailong Zhou
Mar 27, 2018·Animal : an International Journal of Animal Bioscience·S MastrangeloB Portolano
May 25, 2006·Acta Paediatrica. Supplement·Ernest Beutler
Mar 1, 2015·Iranian Journal of Biotechnology·Abdolreza SalehiRohoallah Sobhani
Jun 20, 2019·Current Molecular Medicine·Ying WeiXinhan Zhao
Sep 16, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rongpeng LiMin Wu
Nov 30, 2019·Animals : an Open Access Journal From MDPI·Tomasz SzmatołaMonika Bugno-Poniewierska
Jul 16, 2016·American Journal of Respiratory and Critical Care Medicine·Corry-Anke Brandsma, Wim Timens
Jan 11, 2018·BMC Genomics·Elisa PeripolliMarcos Vinícius Gualberto Barbosa da Silva

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