Cloning and characterization of MUPP1, a novel PDZ domain protein

FEBS Letters
Christoph UllmerH Lubbert

Abstract

Using the yeast two-hybrid system we isolated a cDNA clone encoding a novel protein interacting with the C-terminal domain of the 5-HT2C receptor. The protein, named MUPP1 (multi-PDZ-domain protein), contains thirteen PDZ domains and no obvious catalytic domain; it is related to hINADL and a putative C. elegans polypeptide referred to as C52A11.4 containing six or ten PDZ domains, respectively. Domains highly similar to those of MUPP1 are arrayed in the same order in all three proteins. The MUPP1 gene is localized on human chromosome 9p24-p22. Transcripts encoding MUPP1 are abundant in the brain as well as in several peripheral organs.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F W KluxenH Lübbert
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Apr 1, 1995·Annals of Human Genetics·D P KelsellN K Spurr
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·R A LueA H Chishti
Apr 25, 1994·Nucleic Acids Research·H E FeilotterD Beach
May 1, 1996·The European Journal of Neuroscience·K SchmuckH Lubbert
Aug 15, 1996·Nature·J H Morais CabralR C Liddington
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·S S LeeR T Javier
Jun 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C P PontingD J Blake

❮ Previous
Next ❯

Citations

Sep 1, 2000·Journal of Cellular Biochemistry·D S BarrittW B Stallcup
Sep 5, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ulrich Tepass
Dec 12, 2002·Progress in Biophysics and Molecular Biology·L González-MariscalB E Jaramillo
Oct 5, 2001·Trends in Pharmacological Sciences·G Milligan, J H White
Sep 28, 2000·Trends in Neurosciences·C Heuss, U Gerber
Sep 23, 2003·Brain Research. Molecular Brain Research·Nathalie GriffonPierre Sokoloff
Sep 27, 2002·Current Opinion in Pharmacology·Hans-Jürgen Kreienkamp
Jun 2, 2005·Nature Reviews. Neuroscience·Mary B KennedyLorraine R Washburn
Nov 26, 2008·Oncogene·M ThomasL Banks
Aug 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Miguel A LanaspaTomas Berl
Apr 15, 1999·The EMBO Journal·J Bockaert, J P Pin
May 15, 2002·The EMBO Journal·Carine BécamelPhilippe Marin
Apr 14, 2006·Current Opinion in Psychiatry·Susumu HiguchiHaruo Kashima
Feb 13, 2004·Genes, Brain, and Behavior·C FehrK J Buck
Mar 4, 2009·Molecular and Cellular Biology·Makoto AdachiShoichiro Tsukita
Apr 3, 2001·Annual Review of Neuroscience·M Sheng, C Sala
May 8, 2009·American Journal of Physiology. Renal Physiology·Aleksandra SindicR Tyler Miller
Oct 6, 2000·The Journal of Cell Biology·I M EthellY Yamaguchi
Jul 1, 2006·Critical Reviews in Toxicology·Mathieu VinkenTamara Vanhaecke
Feb 24, 2007·Current Opinion in Cell Biology·Tony Pawson
Mar 27, 2007·Protein Science : a Publication of the Protein Society·Jonathan M ElkinsDeclan A Doyle
Jan 30, 2009·Alcoholism, Clinical and Experimental Research·Victor M KarpyakDoo-Sup Choi
Apr 23, 2003·Brain Research·B SitekH Luebbert
Apr 13, 2004·American Journal of Human Genetics·Shenghan ChenQing Wang
Nov 17, 2007·Biochimica Et Biophysica Acta·Emeline AssématDominique Massey-Harroche
Mar 15, 2008·Biochimica Et Biophysica Acta·Laurent GuillemotSandra Citi
Jun 10, 2008·Journal of Neurochemistry·Marcel A EstévezJay M Baraban
Apr 3, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yuko Sugihara-MizunoShoichiro Tsukita
Jun 28, 2011·British Journal of Pharmacology·Ana C MagalhaesStephen Sg Ferguson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.