Cloning and characterization of the human type II arginase gene

Genomics
J G VockleyStephen D Cederbaum

Abstract

There are two forms of arginase in humans, both catalyzing the hydrolysis of arginine to ornithine and urea. Recent studies in animal models and in Type I arginase-deficient patients suggest that Type II arginase is inducible and may play an important role in the regulation of extra-urea cycle arginine metabolism by modulating cellular arginine concentrations. We PCR amplified and cloned the human Type II arginase gene, the first nonliver arginase gene reported in mammals. While sequence homology to Type I arginase, arginase activity data, and immunoprecipitation with an anti-AII antibody confirm the identity of this gene, Northern blot analysis demonstrates its differential expression in the brain, prostate, and kidney. Type II arginase may be an important part of the arginine regulatory system affecting nitric oxide synthase, arginine decarboxylase, kyotorphin synthase, and arginine-glycine transaminase activities and polyamine and proline biosynthesis.

Citations

Apr 16, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Chia-Ling GauGerald S Lipshutz
Jul 5, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Eun K LeeGerald S Lipshutz
Feb 1, 2006·Clinical and Experimental Pharmacology & Physiology·Ngan Ngoc Huynh, Jaye Chin-Dusting
Jul 25, 2007·Clinical and Experimental Pharmacology & Physiology·William DuranteRobert A Johnson
Jun 8, 2002·Molecular and Cellular Biology·Ramaswamy K IyerStephen D Cederbaum
Jun 11, 2002·Annual Review of Nutrition·Sidney M Morris
Sep 24, 2010·American Journal of Physiology. Cell Physiology·Karina KrotovaSergey Zharikov
Feb 4, 2011·American Journal of Physiology. Cell Physiology·Alia ShatanawiR William Caldwell
Mar 17, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vikram SharmaNathan A Davies
Aug 30, 2012·BMC Systems Biology·Anja KarlstädtHermann-Georg Holzhütter
Sep 27, 2008·Journal of Hematology & Oncology·David J TateArnold H Zea
Apr 6, 2006·Clinical Medicine & Research·Zhihong Yang, Xiu-Fen Ming
Jun 4, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Chuhong HuGerald S Lipshutz
Feb 24, 2015·Nutrients·Karolina A P WijnandsMartijn Poeze
Jun 23, 1998·Experimental Lung Research·M S CarrawayY C Huang
Dec 1, 2012·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Shilpee Srivastava, B K Ratha
Dec 29, 2015·Osteoarthritis and Cartilage·Weidong ZhangGuangju Zhai
Nov 13, 2007·Molecular Genetics and Metabolism·Joshua L DeignanWayne W Grody
Oct 16, 2007·Molecular Genetics and Metabolism·Joshua L DeignanWayne W Grody
Dec 13, 2005·Annals of the New York Academy of Sciences·Claudia R MorrisElliott P Vichinsky
Sep 22, 2009·British Journal of Pharmacology·Markus Munder
Sep 12, 2015·Human Molecular Genetics·Lindsay C BurrageBrendan H Lee
Jun 15, 2006·Journal of Neuroscience Research·Sara G Becker-CataniaRamaswamy K Iyer
Aug 8, 2007·Biotechnology and Bioengineering·Demetra Mavri-DamelinHumphrey J F Hodgson
Jul 30, 2008·The Prostate·Shannon M MumenthalerWayne W Grody
Feb 8, 2005·Molecular Genetics and Metabolism·Eric A Crombez, Stephen D Cederbaum
Oct 16, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yuan Yan SinColin D Funk
Oct 4, 2008·Biochemical and Biophysical Research Communications·Alicja ChrzanowskaAnna Barańczyk-Kuźma
Aug 29, 2006·Molecular Genetics and Metabolism·R M KernS D Cederbaum
May 25, 2006·Placenta·T IshikawaT Aso
Apr 5, 2002·Biochemical Pharmacology·Chang-Li WeiHoon-Eng Khoo
Apr 28, 2005·The American Journal of Pathology·Patricia S Steeg
Dec 21, 2004·Redox Report : Communications in Free Radical Research·Masayasu InoueKozo Utsumi
Aug 8, 2013·Molecular Genetics and Metabolism·Jennifer KastenGerald S Lipshutz
May 2, 2015·Trends in Pharmacological Sciences·Ruth B CaldwellR William Caldwell
Jun 24, 1998·Biochemical and Biophysical Research Communications·S N WaddingtonV Cattell
Sep 14, 2012·Clinical Biochemistry·Yan ZhangMark D Kellogg
Nov 11, 2009·Biochemical and Biophysical Research Communications·Shilpee Srivastava, B K Ratha
Jan 7, 2011·The International Journal of Neuropsychopharmacology·Laura M FioriGustavo Turecki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecular and Cellular Biology
R K IyerStephen D Cederbaum
Molecular Genetics and Metabolism
Eric A Crombez, Stephen D Cederbaum
© 2021 Meta ULC. All rights reserved