Cloning and characterization of the pheromone biosynthesis activating neuropeptide receptor from the silkmoth, Bombyx mori. Significance of the carboxyl terminus in receptor internalization

The Journal of Biological Chemistry
J Joe HullS Matsumoto

Abstract

In most Lepidoptera, pheromone biosynthesis is regulated by a neuropeptide termed pheromone biosynthesis activating neuropeptide (PBAN). Although much is known about the cellular targets of PBAN, identification and functional characterization of the PBAN receptor (PBANR) has proven to be elusive. Given the sequence similarity between the active C-terminal regions of PBAN and neuromedin U, it was hypothesized that their respective receptors might also be similar in structure (Park, Y., Kim, Y. J., and Adams, M. E. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 11423-11428). Consequently, utilizing primers constructed from the conserved regions of insect neuromedin U receptor homologues, a full-length 2780-nucleotide clone encoding a 46-kDa G protein-coupled receptor was amplified from a Bombyx mori pheromone gland cDNA library. Tissue distribution analyses revealed that the receptor transcript is specific to the pheromone gland where it undergoes significant up-regulation in the day preceding eclosion. When transiently expressed in Sf9 cells, the B. mori PBANR responds to PBAN by mobilizing extracellular calcium in a dose-dependent manner. Confocal microscopic studies demonstrated the specificity of enhanced green fluorescent protei...Continue Reading

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Citations

Aug 11, 2007·Bioscience, Biotechnology, and Biochemistry·J Joe HullShogo Matsumoto
Feb 9, 2010·Bioscience, Biotechnology, and Biochemistry·Shogo Matsumoto
Dec 12, 2012·PloS One·Man-Yeon Choi, Robert K Vander Meer
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Atsushi OhnishiShogo Matsumoto
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May 23, 2008·General and Comparative Endocrinology·Ada Rafaeli
Apr 24, 2007·Journal of Insect Physiology·J Joe HullShogo Matsumoto
May 22, 2007·Journal of Insect Physiology·Peter S SternAda Rafaeli
Mar 21, 2007·Insect Biochemistry and Molecular Biology·Man-Yeon ChoiRussell Jurenka
Nov 14, 2015·Annual Review of Entomology·Astrid T GrootDavid G Heckel
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Aug 18, 2010·Communicative & Integrative Biology·J Joe HullShogo Matsumoto
Jun 28, 2016·Biochimica Et Biophysica Acta·Yukie KatayamaMasaru Tanokura

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