Cloning and expression of a cDNA encoding a novel human neurotrophic factor
A cDNA encoding a novel human neurotrophic factor (designated nerve growth factor-2; NGF-2) was cloned from a human glioma cDNA library using a synthetic DNA corresponding to human nerve growth factor (NGF). The cloned cDNA encodes a polypeptide composed of 257 amino acid residues including a prepro-sequence of 138 residues and a mature region of 119 residues. The amino acid sequence of human NGF-2 exhibits 58% similarity with that of human NGF. Conditioned medium of COS-7 cells transfected with an expression plasmid for human NGF-2 cDNA supported the survival of sensory neurons isolated from dorsal root ganglia of embryonic chicks. A 1.5 kb of NGF-2 mRNA can be detected from an early development stage in rat brain, by Northern blotting analysis.
Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family
Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system
Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor
Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose
NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain?
Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs
Differential expression of brain-derived neurotrophic factor and neurotrophin 3 mRNA in lingual papillae and taste buds indicates roles in gustatory and somatosensory innervation
Nerve growth factor (NGF) receptors in a central nervous system glial cell line: upregulation by NGF and brain-derived neurotrophic factor
Brain-derived neurotrophic factor selectively rescues mesencephalic dopaminergic neurons from 2,4,5-trihydroxyphenylalanine-induced injury
Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures
Neurotrophin-3 acquires NGF-like activity after exchange to five NGF amino acid residues: molecular analysis of the sites in NGF mediating the specific interaction with the NGF high affinity receptor
Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins
Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor and beta-nerve growth factor mRNA in rat hippocampus
Preparation of brain-derived neurotrophic factor- and neurotrophin-3-secreting Schwann cells by infection with a retroviral vector
Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex
Expression of BDNF and trkB mRNAs in comparison to dopamine D1 and D2 receptor mRNAs and tyrosine hydroxylase-immunoreactivity in nigrostriatal in oculo co-grafts
Brain-derived neurotrophic factor (BDNF) can prevent apoptosis of rat cerebellar granule neurons in culture
The survival of striatal cholinergic neurons cultured from postnatal 2-week-old rats is promoted by neurotrophins
Intracranial infusion of purified nerve growth factor to an Alzheimer patient: the first attempt of a possible future treatment strategy
Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrains
Molecular mechanisms for generation of neural diversity and specificity: roles of polypeptide factors in development of postmitotic neurons
Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity
Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells
Functions of brain-derived neurotrophic factor, insulin-like growth factor-I and basic fibroblast growth factor in the development and maintenance of dopaminergic neurons
Neurotrophin-3 is expressed in the posterior lobe of mouse cerebellum, but does not affect the cerebellar development
Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system
Entorhinal cortex regulation of multiple brain-derived neurotrophic factor promoters in the rat hippocampus
Response of embryonic rat hippocampal neurons in culture to neurotrophin-3, brain-derived neurotrophic factor and basic fibroblast growth factor
Regulation of neurotrophin and trkA, trkB and trkC tyrosine kinase receptor messenger RNA expression in kindling
Adrenalectomy attenuates kainic acid-elicited increases of messenger RNAs for neurotrophins and their receptors in the rat brain
Role of neurotrophins in the control of neural development: neurotrophin-3 promotes both neuron differentiation and survival of cultured chick retinal cells
Expression of polyadenylated and non-polyadenylated trkC transcripts in the rodent central nervous system
Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain
Analysis of neurotrophin-3 expression using the lacZ reporter gene suggests its local mode of neurotrophic activity
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
Distribution of the neurotrophins brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the postnatal rat brain: an immunocytochemical study
trkB messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study
Eradication of cerebellar granular cells alters the developmental expression of trk receptors in the rat inferior olive
Development of brain-derived neurotrophic factor and neurotrophin-3 immunoreactivity in the lower auditory brainstem of the postnatal gerbil
Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment
Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma
Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity
Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems
Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation
Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation
Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve
Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo
Purification and characterisation of a brain-derived neurotrophic factor/neurotrophin-3 (BDNF/NT-3) heterodimer
Developmentally Regulated Expression of HDNF/NT-3 mRNA in Rat Spinal Cord Motoneurons and Expression of BDNF mRNA in Embryonic Dorsal Root Ganglion
Cellular localization of brain-derived neurotrophic factor and neurotrophin-3 mRNA expression in the early chicken embryo
Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat brain and peripheral tissues
Neurotrophic factors in the tongue: expression patterns, biological activity, relation to innervation and studies of neurotrophin knockout mice
Brain-derived neurotrophic factor is more highly conserved in structure and function than nerve growth factor during vertebrate evolution
Rapid phosphorylation of phospholipase C gamma 1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat cortical neurons
Recombinant human beta-nerve growth factor (NGF): biological activity and properties in an enzyme immunoassay
Developmental changes of neurotrophin-3 level in the mouse brain detected by a highly sensitive enzyme immunoassay
The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells
Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF
Synthesis and purification of biologically active rat brain-derived neurotrophic factor from Escherichia coli
Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations
Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions
Dopaminergic stimulation up-regulates the in vivo expression of brain-derived neurotrophic factor (BDNF) in the striatum
p75 reduces TrkB tyrosine autophosphorylation in response to brain-derived neurotrophic factor and neurotrophin 4/5
Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkC
Characterization of histidine residues essential for receptor binding and activity of nerve growth factor
Stimulation of phosphatidylinositol hydrolysis by brain-derived neurotrophic factor and neurotrophin-3 in rat cerebral cortical neurons developing in culture
Purification and characterization of biologically active recombinant human neurotrophin-3 produced by expression of a chimera gene in Chinese hamster ovary cells
Alteration of NH2-terminal residues of nerve growth factor affects activity and Trk binding without affecting stability or conformation
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
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