PMID: 3755379Aug 15, 1986Paper

Cloning and expression of multiple protein kinase C cDNAs

Cell
J L KnopfR M Bell

Abstract

Three different protein kinase C related cDNA clones were isolated from a rat brain cDNA library and designated PKC-I, PKC-II, and PKC-III. These each encode very similar, but distinct, polypeptides that contain a region homologous with other protein kinases. COS cells transfected with either PKC-I or PKC-II specifically bind at least 5-fold more 3H-PDBu (phorbol ester) than control cells. An increase in Ca2+, phosphatidylserine, and diacylglycerol/phorbol-ester-dependent protein kinase activity is also observed in COS cells transfected with either PKC-I or PKC-II. The physiological implications of the discovery of three protein-kinase-C-related cDNAs are discussed.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1985·Annual Review of Biochemistry·T Hunter, J A Cooper
Sep 9, 1985·Biochimica Et Biophysica Acta·C L Ashendel
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B R GanongR M Bell
Jan 1, 1986·Methods in Enzymology·T KitanoY Nishizuka
Jan 1, 1985·Intervirology·D H Bishop
Jul 5, 1983·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Y Nishizuka
Jun 1, 1984·The Biochemical Journal·M J Berridge
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L M Sompayrac, K J Danna
Mar 11, 1983·Nucleic Acids Research·H Luthman, G Magnusson
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N A SharkeyP M Blumberg
Oct 1, 1984·Archives of Biochemistry and Biophysics·M Shoyab, R Boaze
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M PonczS Surrey
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K O'hareG M Rubin

❮ Previous
Next ❯

Citations

Jan 1, 1996·Journal of Cellular Biochemistry·T Boulikas
Mar 1, 1990·Journal of Cellular Biochemistry·K Saksela
Mar 1, 1993·Journal of Cellular Physiology·L M StoolmanJ Varani
Jun 1, 1994·Journal of Cellular Physiology·A CuadradoC J Molloy
Apr 1, 1992·Muscle & Nerve·S NakanoJ Kimura
Dec 1, 1996·Protein Science : a Publication of the Protein Society·E A Nalefski, J J Falke
Dec 1, 1989·Cancer Metastasis Reviews·C A O'Brian, N E Ward
Jan 1, 1992·Archives of Dermatological Research·A WeversG Mahrle
Dec 1, 1994·Cancer Metastasis Reviews·G C BlobeY A Hannun
Apr 1, 1990·Journal of Protein Chemistry·D S LesterV Brumfeld
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·X J WangJ DiGiovanni
Jan 1, 1990·Journal of Neural Transmission. General Section·R Miyoshi, S Kito
Jan 1, 1993·Agents and Actions·D BradshawS E Wilkinson
Dec 1, 1993·Molecular and Chemical Neuropathology·O Hanson-PaintonP Grammas
Mar 5, 2013·Molecules and Cells·Chang Ho KangCha Young Kim
May 24, 1996·Chemistry and Physics of Lipids·Z Kiss
May 1, 1990·Developmental Biology·J D DavidG P Perrot
Jan 1, 1991·The International Journal of Biochemistry·L H Van den Heever, H W Dirr
Jan 1, 1989·Advances in Enzyme Regulation·H GrunickeH Fiebig
Jan 1, 1991·Pharmacology & Therapeutics·S Stabel, P J Parker
Dec 15, 1990·Brain Research. Developmental Brain Research·W G JiaM S Cynader
Dec 18, 1992·Brain Research. Developmental Brain Research·H M KimS Nomura
Nov 1, 1989·Trends in Neurosciences·K P Huang
Nov 1, 1990·Molecular and Biochemical Parasitology·K KeithA Tait

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.