PMID: 9535132Apr 16, 1998Paper

Cloning and expression of the programmed cell death regulator Bad in the rat brain

Neuroscience Letters
V D'AgataS Cavallaro

Abstract

The Bcl-2 family of proteins consists of both antagonists (e.g. Bcl-2) and agonists (e.g. Bax) that regulate apoptosis and compete through dimerization. In the present study we cloned the cDNA encoding the rat brain BAD, a distant member of the Bcl-2 family that was shown to promote cell death. The cloned cDNA encoded a protein of 205 amino acids, containing three putative Bcl-2 homology domains (BH1, BH2 and BH3) and no C-terminal signal-anchor sequence. The predicted amino acid sequence was identical to the Bad-cDNA recently cloned from the rat ovary with the exception of a stretch of six amino acids, thus indicating the existence of two Bad alternative splice variants or a sequence artifact in the rat ovary Bad-cDNA. Immunohistochemical analysis in the rat brain revealed the exclusive expression of Bad in the epithelial cells of the choroid plexus, a result which is consistent with a very specialized function of Bad in the brain.

References

Oct 1, 1995·Progress in Neurobiology·I Naruse, H Keino
Nov 1, 1996·Virchows Archiv : an International Journal of Pathology·A HaraH Mori
Jan 1, 1997·Annual Review of Neuroscience·D E Merry, S J Korsmeyer
Sep 26, 1997·The Journal of Biological Chemistry·J ZhaS J Korsmeyer

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Citations

Jun 15, 1999·Brain Research. Developmental Brain Research·D W RickmanC Bowes Rickman

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