PMID: 11900977Mar 20, 2002Paper

Cloning and expression of Ventrhoid, a novel vertebrate homologue of the Drosophila EGF pathway gene rhomboid

Mechanisms of Development
József Jászai, Michael Brand

Abstract

In Drosophila melanogaster, the seven-pass transmembrane protein Rhomboid (Rho) is a crucial positive modulator of EGF signaling playing a substantial role in patterning of the ventral neuroectoderm and fate specification of neuroblasts. Here, we describe the cloning and expression pattern of Ventrhoid (Vrho), the novel evolutionarily conserved vertebrate cDNA related to fruit fly rho. Most importantly, like rho in Drosophila, Vrho is also expressed in a spatially restricted manner. Vrho expression is most prominent along the developing ventral neural tube, and is also detectable in the ventral forebrain, prospective diencephalon, otic vesicles, mandibular arches, cranial sensory placodes, last formed pair of somites and hindgut in midgestational mouse embryos.

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Citations

Mar 30, 2004·Biochemical and Biophysical Research Communications·John C Pascall, Kenneth D Brown
Aug 30, 2002·Current Opinion in Genetics & Development·Sinisa Urban, Matthew Freeman
Feb 14, 2008·PloS One·Jeffrey M TrimarchiConstance L Cepko
Jan 26, 2006·Anatomia, histologia, embryologia·A Kacperczyk, M Daczewska
Nov 28, 2012·Neurobiology of Aging·Azad KumarMark R Cookson
Aug 9, 2016·Seminars in Cell & Developmental Biology·Viorica L LastunMatthew Freeman
Oct 23, 2016·Seminars in Cell & Developmental Biology·Kvido Strisovsky
Mar 3, 2004·Nature Reviews. Molecular Cell Biology·Matthew Freeman
Jun 21, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Takatoshi NakagawaRik Derynck
May 4, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Stefan DüsterhöftMatthew Freeman

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