PMID: 11906934Mar 22, 2002Paper

Cloning and expression of zebra finch (Taeniopygia guttata) steroidogenic factor 1: overlap with hypothalamic but not with telencephalic aromatase

Biology of Reproduction
Robert J AgateArthur P Arnold

Abstract

The zebra finch (Taeniopygia guttata) brain is highly sexually dimorphic. The organization and production of sex-specific song is considerably influenced by estrogens and androgens. Because the brain itself expresses several steroidogenic enzymes, the local production of sex steroids may contribute to sex differences in neural development. Sex steroid production in gonads is directed by a master regulatory factor, steroidogenic factor 1 (SF1). We have identified a cDNA encoding the homologue of SF1 in the zebra finch and utilized reverse transcription-polymerase chain reaction and in situ hybridization to examine early and late developmental expression of SF1 in brain and in early gonadal development. We found that SF1 is expressed early in embryonic development in the Rathke pouch, beginning at stage 15 and extending to at least stage 27 in both males and females. The earliest expression of SF1 in gonads was found at stage 17 for both males and females and extended to at least stage 27. In brain, we assessed SF1 mRNA expression in posthatch and adult telencephalon, and we compared SF1 and aromatase mRNA expression in adult hypothalamus. In the telencephalon and hippocampus, aromatase was expressed independently of SF1, whereas...Continue Reading

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Citations

Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Sok-Keng Tong, Bon-chu Chung
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robert J AgateArthur P Arnold
Jul 11, 2006·Frontiers in Neuroendocrinology·Paul M ForlanoAndrew H Bass
Nov 20, 2012·Brain Research Bulletin·Juli WadeYu Ping Tang
Apr 19, 2016·Brain Research·Linda Qi BeachJuli Wade
Jan 1, 2003·The Journal of Comparative Neurology·William R PerlmanArthur P Arnold

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