Cloning and functional expression of a novel isoform of ROMK inwardly rectifying ATP-dependent K+ channel, ROMK6 (Kir1.1f)

FEBS Letters
C KondoYoshihisa Kurachi

Abstract

We have identified from rat kidney a novel isoform of ROMK/Kir1.1, designated ROMK6/Kir1.1f. ROMK6 was nearly identical to ROMK1, but possessed an 122-bp insertion in the 5' region. Its deduced amino acid sequence was shorter by 19 amino acids than that of ROMK1 in the amino-terminus. Unlike other previously reported ROMK isoforms, ROMK6 mRNA was ubiquitously expressed in various tissues, including kidney, brain, heart, liver, pancreas and skeletal muscle. Xenopus oocytes injected with ROMK6 cRNA expressed a Ba2+-sensitive weakly inwardly rectifying K+ current. These results indicate that ROMK6 is a novel functional K+ channel and might be involved in K+ secretion in various tissue.

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Citations

Jul 25, 2003·The Journal of Membrane Biology·R Warth, J Barhanin
Dec 15, 2000·Acta Physiologica Scandinavica·G Giebisch, W Wang
Sep 21, 2000·European Journal of Biochemistry·U Schulte, B Fakler
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Jul 16, 2008·Physiological Reviews·Dirk Heitzmann, Richard Warth
Jan 21, 2010·Physiological Reviews·Hiroshi HibinoYoshihisa Kurachi
Dec 30, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fumiya FurukawaToyoji Kaneko
Apr 14, 2018·Molecular Pharmacology·Atsushi InanobeYoshihisa Kurachi
Dec 30, 2014·The Journal of Physiology·Marino DiFrancoJulio L Vergara
Dec 15, 2015·Physiological Reviews·Monique N Foster, William A Coetzee
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Aug 27, 2009·The Journal of Comparative Neurology·Gennady DvoryanchikovNirupa Chaudhari
Jun 3, 2000·American Journal of Physiology. Renal Physiology·P A MennittL G Palmer

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