Cloning and mapping of human chromosome 6q26-q27 deleted in B-cell non-Hodgkin lymphoma and multiple tumor types

Genomics
R S HauptscheinR Dalla-Favera

Abstract

Frequent deletions of the distal region on the long arm of chromosome 6 have been reported in multiple human tumors including B-cell non-Hodgkin lymphoma (B-NHL), suggesting the presence of one or more tumor suppressor genes (TSGs) at this locus. Previously, we identified a region of minimal molecular deletion at 6q25-q27 (RMD-1) in B-NHL cases. To facilitate positional cloning efforts to identify the RMD-1 TSG(s), a yeast artificial chromosome (YAC) contig consisting of 110 clones was constructed across 6q26-q27 by sequence-tagged site/probe content mapping. The contig integrates 79 ordered markers including restriction fragment length polymorphisms, minisatellites, microsatellites, YAC-insert termini, expressed sequence tags, and known genes. It spans 34 cM and has a minimal tiling path of approximately 12 clones, covering an estimated 9-14 Mb with nearly every marker on the map showing at least double linkage to its adjacent markers. Dual-color fluorescence in situ hybridization of selected marker pairs on normal pachytene chromosome 6 further confirmed the YAC-based mappings. Utilizing a loss of constitutional heterozygosity assay in the B-NHL tumor panel, 24 additional 6q26-q27 polymorphic markers (21 mapping to the contig...Continue Reading

References

Aug 1, 1992·Human Molecular Genetics·F A HolE C Mariman
Dec 25, 1991·Nucleic Acids Research·R HauptscheinG Gaidano
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Z LarinH Lehrach
Jan 1, 1982·Cytogenetics and Cell Genetics·S C JhanwarR S Chaganti
Jul 15, 1994·International Journal of Cancer. Journal International Du Cancer·G J WalkerN K Hayward
Sep 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·V P ShortleY H Edwards
Sep 1, 1995·Genes, Chromosomes & Cancer·L QueimadoS Castedo
Dec 22, 1995·Science·T J HudsonE S Lander
Jan 12, 1996·The Journal of Biological Chemistry·M KuriyamaK Kaibuchi
Jul 1, 1996·Human Molecular Genetics·J L DaviesJ A Todd
Feb 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·I E CookeT S Ganesan
Oct 25, 1996·Science·G D SchulerT J Hudson
Oct 1, 1996·Trends in Genetics : TIG·M HeiskanenA Palotif
Jan 1, 1996·DNA Sequence : the Journal of DNA Sequencing and Mapping·S AbdullaS Beck
Aug 1, 1997·Nature Genetics·D Haber, E Harlow
Feb 21, 1998·Nucleic Acids Research·S I LetovskyP W Li
Oct 16, 1999·DNA Sequence : the Journal of DNA Sequencing and Mapping·X Y QuJ J Russo

❮ Previous
Next ❯

Citations

Dec 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Francesco AcquatiRoberto Taramelli
Oct 16, 1999·DNA Sequence : the Journal of DNA Sequencing and Mapping·X Y QuJ J Russo
Aug 27, 2003·Genes, Chromosomes & Cancer·Daniel T Y ChuiRuth F Jarrett
Sep 29, 2011·Annals of Human Genetics·Ji-Yun LeeGene Hallford
Mar 11, 2006·Cancer Genetics and Cytogenetics·M TaborelliCarlo Capella
Apr 20, 2006·Archives of Biochemistry and Biophysics·Paola CampomenosiRoberto Taramelli
Nov 1, 2011·Cell·Elisa OricchioHans-Guido Wendel
Nov 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andreas ViardotMartin Bentz
Dec 17, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S P TreonC C Morton
Dec 14, 2007·The Journal of Urology·Robert S SvatekShahrokh F Shariat
Nov 28, 2001·Hematology·N L HarrisW C Chan
Oct 25, 2003·Oncogene·Kathleen W Scotto
Jan 31, 2003·Journal of Inherited Metabolic Disease·I KnerrG F Hoffmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.