PMID: 6963223Jan 1, 1982Paper

Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA

DNA
M M Cohen-SolalB G Forget

Abstract

Clones of human embryonic alpha-like zeta-globin cDNA were isolated, by detection using cross-hybridization to human alpha-globin cDNA probes, from a cDNA library derived from the mRNA of the human erythroleukemia cell line K562. Nucleotide sequence analysis of these cDNA clones revealed a coding sequence that corresponds perfectly to the independently derived amino acid sequence of the human zeta-globin chain. Comparison of the nucleotide sequence of human zeta-globin cDNA with that of human alpha-globin cDNA confirmed previous estimates of very distant evolutionary divergence between the human zeta- and alpha-globin genes. Nevertheless, the human zeta-globin cDNA sequence shares a remarkable similarity to that of the alpha-globin gene in its codon usage, high G + C base composition, and lack of bias against usage of CG dinucleotides.

References

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Citations

Mar 1, 1990·Journal of Molecular Evolution·C W Schmid, J Marks
Feb 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·S C HeffelfingerG J Darlington
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P TchenM Leng
Mar 17, 2006·Hemoglobin·Rachel J CookW Edward Highsmith
Aug 1, 1989·American Journal of Hematology·C C ThompsonM Vacovsky
Dec 31, 1997·American Journal of Medical Genetics·N M LindorS Jalal
Mar 1, 1987·Human Genetics·T HenniJ Godet
Oct 1, 1992·Clinical Genetics·N TommerupG B Petersen

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