PMID: 8972568Jan 1, 1996Paper

Cloning and sequence analysis of a Marek's disease virus origin binding protein (OBP) reveals strict conservation of structural motifs among OBPs of divergent alphaherpesviruses

Virus Genes
T F WuP M Coussens

Abstract

Marek's disease virus (MDV) is a highly cell-associated avian herpesvirus. In its natural host, MDV induces Marek's disease (MD), a lethal condition characterized by malignant lymphoma of T cells. Although symptoms of MD may be prevented by vaccination, no practical pharmacological method of control has been widely accepted. Viral replication represents a point at which pharmacological control of herpesvirus infection may be most successful. However, this requires detailed knowledge of viral replication proteins. Studies in HSV-1 DNA replication implicate the UL9 protein as a key initiator of replication. For example, binding of UL9 to HSV-1 origins is a prerequisite for assembly of additional replication proteins. In this study, a protein, whose apparent molecular size is similar to that of HSV-1 UL9, was identified in extracts of MDV infected cells by western blot analysis with anti-HSV-1 UL9 antibody. A putative MDV UL9 gene was subsequently identified through sequencing of MDV genome fragments (BamHI G and C). Extended DNA sequence analysis revealed an open reading frame (ORF) which could encode a protein homologous to HSV-1 UL9. The MDV UL9 ORF encodes 841 amino acids, producing a sequence 49% identical to HSV-1 UL9 and 46...Continue Reading

References

Mar 1, 1989·Journal of Virology·R P BaumannD J O'Callaghan
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Feb 1, 1988·Journal of Virology·D J McGeochM D Challberg
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P Elias, I R Lehman
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Oct 1, 1988·Molecular and Cellular Biology·D Lockshon, D A Galloway
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J CebrianP Sheldrick
Jun 1, 1994·Journal of Virology·D W Martin, S Deb
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