PMID: 11912046Mar 26, 2002Paper

Cloning and sequencing of a novel metallothionein gene in Mytilus galloprovincialis Lam

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
N CerattoA Viarengo

Abstract

Metallothionein (MT) is a ubiquitous, metal-inducible protein with an important role in the homeostasis and in the detoxification of heavy metals. This work reports the cloning and sequencing of a MT gene encoding a MT isoform (MT20-IIIa) in the mussel Mytilus galloprovincialis Lam, a lamellibranch mollusc known to accumulate and to detoxify large amounts of metal. The MT gene, lacking the 5' promoter region, is 1865 bp long and has a tripartite structure consisting of three exons and two introns. The putative open reading frame (ORF) encodes a polypeptide of 72 amino acids, which corresponds to the MT-I class, type 2 family (http://www.unizh.ch/~mtpage/classif.html). The structure of the gene and the putative MT20-III protein have been compared with those of other species. The putative biological significance of the differences at the amino acid level among the different MTs is discussed.

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Citations

Jul 26, 2012·Environmental Science and Pollution Research International·Eun-Ji WonJae-Seong Lee
May 10, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Dries KnapenRonny Blust
Jan 14, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Bernhard Lieb
Nov 1, 2009·Environmental Toxicology and Pharmacology·Vladimir MićovićBiserka Radošević-Stašić
Dec 6, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Vincent Leignel, Marc Laulier
Apr 5, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Rubén OrihuelaSílvia Atrian
May 3, 2005·Marine Biotechnology·V LeignelM Laulier

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