PMID: 8612793Mar 25, 1996Paper

Cloning and sequencing of the 5' region of the human glucose-6-phosphatase gene: transcriptional regulation by cAMP, insulin and glucocorticoids in H4IIE hepatoma cells

FEBS Letters
D SchmollA Burchell

Abstract

We have cloned and sequenced the first 1.2 kb of the 5' region of the human glucose-6-phosphatase gene. Transfection of H4IIE hepatoma cells with the 1.2 kb fragment fused to a luciferase reporter gene demonstrated both basal and hormone responsive luciferase activity. Dexamethasone increased and insulin decreased luciferase activity. Insulin and dibutyryl cyclic AMP both significantly decreased activity in the presence of dexamethasone.

References

Jun 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Burchell
Jan 1, 1992·Annual Review of Physiology·S J Pilkis, D K Granner
Feb 1, 1990·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·R R Traxinger, R C Nordlie
Sep 30, 1986·Biochemical and Biophysical Research Communications·R C Garland
May 1, 1983·Archives of Biochemistry and Biophysics·S L IyerC C Widnell
Sep 12, 1995·Biochimica Et Biophysica Acta·M W VoiceA Burchell
Oct 1, 1994·Molecular Membrane Biology·A BurchellR Hume
Oct 1, 1994·The Biochemical Journal·F P Lemaigre, G G Rousseau

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Citations

Jan 22, 1998·The Journal of Clinical Endocrinology and Metabolism·P MarcolongoA Burchell
Mar 20, 1998·The Journal of Clinical Endocrinology and Metabolism·I YoshiuchiY Matsuzawa
Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·Roldan M de GuiaStephan Herzig
Aug 17, 1999·Annual Review of Nutrition·R C NordlieA J Lange
Mar 11, 2000·European Journal of Biochemistry·G van de WerveA Berteloot
Jan 31, 2003·The Journal of Biological Chemistry·Beth T Vander KooiRichard M O'Brien
May 27, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Laura ForsythAnn Burchell
Jul 13, 2012·American Journal of Physiology. Endocrinology and Metabolism·Debora EspositoIlya Raskin
Feb 19, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ingrit HamannLars-Oliver Klotz
Jan 7, 2003·The Journal of Nutrition·Michael J PagliassottiMichael E Bizeau
Mar 29, 2019·Chronobiology International·Shumin SunHiroaki Oda
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·R S StreeperR M O'Brien
Sep 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·L A HornbuckleR M O'Brien
Jan 9, 2001·Nature Cell Biology·C N ShenD Tosh
Oct 13, 2016·The Journal of Endocrinology·C García-LunaP de Gortari
Feb 18, 2010·American Journal of Physiology. Endocrinology and Metabolism·Dale S EdgertonAlan D Cherrington
Oct 20, 2020·Frontiers in Endocrinology·Laura Van MoortelKarolien De Bosscher
Dec 31, 1997·The American Journal of Physiology·C S DeutschmanR Taub
Nov 26, 2020·Metabolism Open·Toyin Mohammed SalmanSheu Oluwadare Sulaiman
Apr 26, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·R ChenS L Woo
Dec 20, 2002·Mechanisms of Development·Chia Ning ShenDavid Tosh
May 1, 1997·Metabolism: Clinical and Experimental·S MetzgerT Chajek-Shaul
Feb 15, 2005·Early Human Development·Robert HumeDaisy K M Koh
Mar 7, 2006·Biochemical and Biophysical Research Communications·Guohong LiuQi-Xiang Li
Jul 13, 2007·Molecular and Cellular Endocrinology·Alexandros Vegiopoulos, Stephan Herzig

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