Cloning and structural analysis of a gene encoding a mouse mastocytoma proteoglycan core protein; analysis of its evolutionary relation to three cross hybridizing regions in the mouse genome

Gene
T AngerthL Hellman

Abstract

Serglycin (SGC) is a Ser-Gly-repeat-containing protein, used as a proteoglycan core protein in the parietal yolk sac and in mast cells, where glycosaminoglycan side chains are attached to the serine residues of the repeat region. In this article, the structure of the gene SGC encoding mouse SGC is reported. The gene is divided into three exons, which are all contained within a region of approximately 13 kb. Nucleotide (nt) sequence analysis was carried out on a region of 1.2 kb upstream from the first exon. The region containing the two promoters (active in parietal yolk sac and in mast cells, respectively) was analyzed for the presence of recognition sites for known DNA-binding proteins. A number of sequences closely related to known recognition sites were found in both promoters, and one consensus octamer-binding site could be identified in the putative yolk-sac promoter. Multiple regions in the mouse genome hybridizing with DNA fragments covering the Ser-Gly repeat region have previously been described, and it has been suggested that these loci may represent other proteoglycan core proteins. Analysis of nt sequence was carried out on three out of the more than 15 of these regions present in the mouse genome. However, none of...Continue Reading

References

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Citations

May 15, 1993·Experientia·H KresseE Schönherr
Apr 23, 2003·Biochemical and Biophysical Research Communications·Yuan-Qing YaoKai-Fai Lee
Dec 4, 2013·Cellular & Molecular Biology Letters·Agata Piecuch, Ewa Obłąk
Jun 18, 2020·International Journal of Molecular Sciences·Rangita DawadiJan-Olof Winberg
Jan 10, 2018·Frontiers in Immunology·Lars Torkel HellmanZhirong Fu
Nov 28, 2000·European Journal of Immunology·C LunderiusL Hellman
Oct 1, 1991·Current Opinion in Cell Biology·J D Esko

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