Cloning and structural analysis of the murine GCN5L1 gene

Gene
C A DriessenJ J Janssen

Abstract

We recently cloned the murine 11-cis retinol dehydrogenase gene. A second gene, the murine GCN5L1 gene, was found to be situated upstream of the murine 11-cis retinol dehydrogenase gene. We have isolated and sequenced the complete coding sequence of the murine GCN5L1 gene. The distance between the 3'-end of the murine GCN5L1 gene and the 5'-end of the 11-cis retinol dehydrogenase gene is only 776 nt. The murine GCNSL1 gene consists of four exons encompassing approximately 3.5 kb of genomic DNA. Intron/exon splice sites conform to the GT/AG rule. The open reading frame consists of 375 nucleotides encoding a 14 kDa protein. The murine GCN5L1, like the human GCN5L1 protein, displays weak homology (27%) to yeast GCN5. The distance between the murine, human and bovine GCN5L1 and 11-cis retinol dehydrogenase genes appeared to be conserved.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 1, 1995·Investigative Ophthalmology & Visual Science·C A DriessenJ J Janssen
Oct 1, 1996·Photochemistry and Photobiology·R K CrouchD R Pepperberg

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Citations

Jun 8, 2001·Progress in Retinal and Eye Research·J K McBeeD R Pepperberg
May 22, 2010·Progress in Retinal and Eye Research·Valerie C Fleisch, Stephan C F Neuhauss
Jul 10, 2007·Experimental Eye Research·Albert MunizAndrew T C Tsin
Jul 1, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Kaiyuan WuMichael N Sack
Feb 27, 2018·Trends in Cell Biology·Iain ScottMichael N Sack

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