Cloning and subcellular location of an Arabidopsis receptor-like protein that shares common features with protein-sorting receptors of eukaryotic cells

Plant Physiology
S U AhmedN V Raikhel

Abstract

Many receptors involved in clathrin-mediated protein transport through the endocytic and secretory pathways of yeast and animal cells share common features. They are all type I integral membrane proteins containing cysteine-rich lumenal domains and cytoplasmic tails with tyrosine-containing sorting signals. The cysteine-rich domains are thought to be involved in ligand binding, whereas the cytoplasmic tyrosine motifs interact with clathrin-associated adaptor proteins during protein sorting along these pathways. In addition, tyrosine-containing signals are required for the retention and recycling of some of these membrane proteins to the trans-Golgi network. Here we report the characterization of an approximately 80-kD epidermal growth factor receptor-like type I integral membrane protein containing all of these functional motifs from Arabidopsis thaliana (called AtELP for A. thaliana Epidermal growth factor receptor-Like Protein). Biochemical analysis indicates that AtELP is a membrane protein found at high levels in the roots of both monocots and dicots. Subcellular fractionation studies indicate that the AtELP protein is present in two membrane fractions corresponding to a novel, undefined compartment and a fraction enriched ...Continue Reading

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Citations

Jan 19, 2005·Planta·Sivakumar PattathilMaor Bar-Peled
Oct 21, 2006·Planta·Elizabeth D JohnsonMarilyn A Anderson
Dec 8, 2005·Protoplasma·F G MasclauxR Pont-Lezica
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Oct 3, 1999·The Plant Journal : for Cell and Molecular Biology·D C Bassham, N V Raikhel
Apr 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Delphine GendreRishikesh P Bhalerao
Jul 11, 2000·Molecular Biology of the Cell·D C BasshamN V Raikhel
Feb 18, 2003·Molecular Biology of the Cell·Enrique RojoNatasha V Raikhel
Dec 21, 2002·Journal of Experimental Botany·Valérie LavalJean-Philippe Galaud
Jun 18, 2002·Plant Physiology·Haiyan ZhengNatasha V Raikhel
Aug 6, 2008·Plant Physiology·David G RobinsonKarin Schumacher
Oct 8, 2008·Plant Physiology·Inhwan Hwang
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Apr 24, 1999·The Plant Cell·A A Sanderfoot, N V Raikhel

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