PMID: 3767336Aug 1, 1986Paper

Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons

Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology
V I Savel'evA P Bolotin

Abstract

Four different recombinant phages carrying interferon sequences were identified in the human gene bank on vector Charon 4A. A fragment of interferon A gene cloned previously through cDNA was used as a hybridization probe for analysis of the bank. The nucleotide sequence of DNA encoding the interferon genes was determined for 2 recombinant phages. One of these genes corresponded to the interferon A gene but one amino acid substitution (His 34-Arg). The second gene (I1) belonged to the family of the interferon C genes and differed from all the genes described earlier.

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