Cloning and tissue distribution of the chicken type 2 corticotropin-releasing hormone receptor

General and Comparative Endocrinology
Bert De GroefVeerle M Darras

Abstract

We report the cloning of the complete coding sequence of the putative chicken type 2 corticotropin-releasing hormone receptor (CRH-R2) by rapid amplification of cDNA ends (RACE). The chicken CRH-R2 is a 412-amino acid 7-transmembrane G protein-coupled receptor, showing 87% identity to the Xenopus laevis and Oncorhynchus keta CRH-R2s, and 78-80% to mammalian CRH-R2s. The distribution of CRH-R2 mRNA was studied by RT-PCR analysis and compared to CRH-R1 distribution. Both CRH-R1 and CRH-R2 mRNA are expressed in the main chicken brain parts. In peripheral organs, CRH-R1 mRNA shows a more restricted distribution, whereas CRH-R2 mRNA is expressed in every tissue investigated, indicating that a number of actions of CRH and/or CRH-like peptides remain to be discovered in the chicken as well as in other vertebrates.

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Citations

Mar 19, 2013·General and Comparative Endocrinology·Wayne J KuenzelAlexander Jurkevich
Apr 21, 2007·Neuroscience Letters·Hiroshi KamisoyamaShin Hasegawa
Jan 24, 2006·General and Comparative Endocrinology·Christopher A Lowry, Frank L Moore
Dec 31, 2005·General and Comparative Endocrinology·Yoichi ItoSakaé Kikuyama
Apr 11, 2017·The Journal of Comparative Neurology·Sylvia V H GrommenBert De Groef
Mar 24, 2010·Poultry Science·W J Kuenzel, A Jurkevich
Jul 9, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ian A BouyoucosW Gary Anderson

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