PMID: 9445394Mar 7, 1998Paper

Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver

The Biochemical Journal
K KatayamaS Yamashita

Abstract

An alternatively spliced isoform of ADP-ribosylation-factor-dependent phospholipase D (PLD1) was previously shown to occur in rat C6 cells [Yoshimura, Nakashima, Ohguchi, Sakai, Shinoda, Sakai and Nozawa (1996) Biochem. Biophys. Res. Commun. 225, 494-499] and human HeLa cells [Hammond, Jenco, Nakashima, Cadwallader, Gu, Cook, Nozawa, Prestwich, Frohman and Morris (1997) J. Biol. Chem. 272, 3860-3868]. However, its complete sequence and the enzymological difference between the two PLD1 isoforms were unclear. Here we report the cloning, complete sequence, enzymological properties and tissue distribution of each of the two alternatively spliced PLD1 isoforms, a and b, from rat liver. The major difference between the two isoforms was the deletion of 38 amino acids in the b isoform, but otherwise the two cDNA sequences were 99.9% identical. The a-isoform sequence was 91% identical with the a form of human PLD1, and the 38-amino-acid deletion in the b form occurred at the same site as in the b form of human PLD1. Both of the rat PLD1 isoforms expressed in the fission yeast Schizosaccharomyces pombe were dependent on ADP-ribosylation factor 1 and phosphatidylinositol 4,5-bisphosphate. The a isoform was activated by RhoA in a synergist...Continue Reading

Citations

Jan 28, 1999·The Journal of Biological Chemistry·T C SungM A Frohman
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Mark McDermottAndrew J Morris
Dec 24, 2004·Molecular Biology of the Cell·Hiba KomatiGeorges Némoz
Apr 14, 2007·Journal of Leukocyte Biology·Julian Gomez-CambroneroKatie Knapek
Aug 1, 2000·Endocrinology·Meng-Chi ChenDe Cio L Eizirik
Dec 4, 2002·Immunology·Youngkyun LeeMyung-Un Choi
Apr 12, 2007·Journal of Biochemical and Molecular Toxicology·Mercedes Fernández SantiagoMiguel A Pérez-Albarsanz
Dec 10, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Meera Nanjundan, Fred Possmayer
Dec 29, 1998·The Journal of Biological Chemistry·T C SungM A Frohman
Apr 15, 2000·The Journal of Biological Chemistry·C LeeS G Rhee
Mar 22, 2001·The Journal of Biological Chemistry·K OishiY Ono
Jun 27, 2020·Antioxidants & Redox Signaling·Nickolas AuclairEmile Levy
Dec 13, 2019·Progress in Lipid Research·M I McDermottV A Bankaitis
Dec 10, 2020·International Journal of Molecular Sciences·Marek KrzystanekArtur Pałasz
Jul 30, 1999·Biochimica Et Biophysica Acta·M G Houle, S Bourgoin
Dec 5, 1998·Biochimica Et Biophysica Acta·J H Exton
May 23, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S A Rooney
Sep 5, 1998·Brain Research. Developmental Brain Research·D ZhaoJ K Blusztajn
Jul 30, 1999·Biochimica Et Biophysica Acta·K E MeierK M Ella
Jul 30, 1999·Biochimica Et Biophysica Acta·M LiscovitchX Tang
Jul 30, 1999·Biochimica Et Biophysica Acta·J H Exton
Jul 30, 1999·Biochimica Et Biophysica Acta·M A FrohmanA J Morris
Jul 19, 2005·Molecular and Cellular Endocrinology·Annika K AnderssonStellan Sandler
Sep 23, 2011·Chemical Reviews·Paige E SelvyH Alex Brown
May 31, 2011·The International Journal of Biochemistry & Cell Biology·Troy A Hornberger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.