PMID: 9180361Jan 1, 1997Paper

Cloning, functional expression and tissue distribution of rabbit alpha1a-adrenoceptor

Life Sciences
S MiyamotoI Muramatsu

Abstract

A cDNA clone, which has an open reading frame of 1398 nucleotides encoding a 466-amino-acid peptide, has been isolated from rabbit liver cDNA library. Compared with the peptide sequence, it shows high homology to alpha1a adrenoceptors of human, bovine and rat. We expressed this clone in COS-7 and investigated the pharmacological properties, revealing similarity to those of human alpha1a adrenoceptors. Competitive RT/PCR has detected the mRNA in variety of rabbit tissues, especially abundantly in liver, vas deferens, brain, and aorta, but not in heart.

References

Jan 1, 1990·British Journal of Pharmacology·I MuramatsuM Oshita
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G GillilandH F Bunn
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S CotecchiaB K Kobilka
Jul 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·M C MichelD A Schwinn
Aug 24, 1995·Biochemical and Biophysical Research Communications·C FaureD Graham
Jun 1, 1994·Trends in Pharmacological Sciences·A P FordD E Clarke
Jan 1, 1994·Annual Review of Pharmacology and Toxicology·K P Minneman, T A Esbenshade
Sep 15, 1993·Biochemical and Biophysical Research Communications·A HirasawaG Tsujimoto
May 1, 1996·Circulation Research·R M GrahamM T Piascik

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Citations

Aug 31, 2001·European Journal of Pharmacology·C González-EspinosaJ A García-Sáinz
Mar 4, 1999·European Journal of Pharmacology·Y HiraokaI Muramatsu
Sep 7, 2002·Life Sciences·Akito TanoueGozoh Tsujimoto
May 5, 2001·Pharmacology & Therapeutics·G A MichelottiD A Schwinn
Aug 5, 1999·British Journal of Pharmacology·T TaniguchiI Muramatsu
Apr 26, 2000·British Journal of Pharmacology·F SuzukiI Muramatsu
Jun 4, 2016·PloS One·R Croft ThomasPaul C Simpson
Jan 11, 2002·European Journal of Biochemistry·Xiankun BaoRichard J Haslam
Jan 25, 2000·Experimental Eye Research·A Wikberg-MatssonJ E Wikberg

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