Cloning, mapping, genomic organization, and expression of mouse M-LP, a new member of the peroxisomal membrane protein Mpv17 domain family

Biochemical and Biophysical Research Communications
R IidaK Kishi

Abstract

We have identified a mouse full-length cDNA and gene encoding a novel protein (M-LP), based on an expressed sequence tag (EST) sequence (GenBank Accession No. AI482564) obtained by differential display screening of age-dependently expressed genes in mouse kidney. The ML-P gene is composed of three exons, ranges over 5 kb on mouse chromosome 16B1-B2 and is expressed as two transcripts (1455 and 3058 bp), both of which include the same open-reading frame encoding 194 amino acids. M-LP is expressed mainly in kidney and spleen and shows age-dependent expression. M-LP has sequence homologies and membrane topologies very similar to the Mpv17 protein, a peroxisomal protein involved in the development of early-onset glomerulosclerosis. Search of the protein domain family database (ProDom) revealed that M-LP is a new member of the Mpv17 domain family (PD008400).

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Citations

Sep 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stefanie KrickErwin P Böttinger
Nov 26, 2009·Genome Génome / Conseil National De Recherches Canada·Charalambos MagoulasLuis Lopez de Heredia
Feb 11, 2012·Cell and Tissue Research·Angela-Maria Meyer zum GottesbergeStefan Hansen
Mar 1, 2008·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Etsuko TsubotaReiko Iida
Apr 25, 2006·Biochemical and Biophysical Research Communications·Reiko IidaKoichiro Kishi
Apr 12, 2005·Biochimica Et Biophysica Acta·Mika MasuyamaTakasumi Matsuki
Mar 30, 2010·Biochimica Et Biophysica Acta·M IslingerM Schrader
Sep 5, 2007·Molecular & Cellular Proteomics : MCP·Sebastian WieseBettina Warscheid
Dec 19, 2006·The Biochemical Journal·Wouter F VisserRonald J A Wanders
Sep 4, 2021·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Yu PanNa Song
Jul 6, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Reiko IidaToshihiro Yasuda

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