PMID: 9531470Jun 11, 1998Paper

Cloning of a functional promoter of the human sodium/iodide-symporter gene

The Biochemical Journal
M BehrUlrich Loos

Abstract

We have cloned and sequenced genomic DNA from a human library extending 1300 bp upstream the 5'-untranslated sequence of the cDNA coding for the sodium/iodide symporter. In transient transfection assays this sequence exhibited promoter activity, which could be confined to nucleotides -443 to -395 relative to the ATG start codon. This minimal promoter, including a putative GC- and TATA- box, was preferentially activated in the rat thyroid cell line FRTL-5, but was also active in non-thyroidal cells, such as COS-7 and Chinese-hamster ovary, albeit to a markedly lower extent.

Citations

Jun 12, 1999·Thyroid : Official Journal of the American Thyroid Association·W JobaA E Heufelder
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·G M VenkataramanK B Ain
May 12, 2000·Thyroid : Official Journal of the American Thyroid Association·C SpitzwegJ C Morris
May 30, 2002·Thyroid : Official Journal of the American Thyroid Association·Thomas L SchmittUlrich Loos
Feb 18, 2003·Endocrine Reviews·Orsolya DohánNancy Carrasco
Mar 28, 2013·Thyroid : Official Journal of the American Thyroid Association·Mariateresa PuglieseMaria Graziella Catalano
Dec 13, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Meike L SchipperThomas M Behr
Jul 7, 2000·Thyroid : Official Journal of the American Thyroid Association·C Schmutzler, J Köhrle
Jul 21, 2006·BMC Cancer·Cinzia PuppinGiuseppe Damante
Feb 14, 2007·Oncogene·K BoelaertC J McCabe
Mar 11, 2004·Thyroid : Official Journal of the American Thyroid Association·Xiaoqin LinSissy M Jhiang
Mar 28, 2002·Thyroid : Official Journal of the American Thyroid Association·Jimin XuJerome M Hershman
Jun 9, 2001·Thyroid : Official Journal of the American Thyroid Association·D H ShenS M Jhian
Oct 23, 2002·Clinical Endocrinology·Christine Spitzweg, John C Morris
Sep 29, 2001·Thyroid : Official Journal of the American Thyroid Association·A E HeufelderW Joba
Apr 12, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Michael J WillhauckChristine Spitzweg
Mar 9, 2000·Trends in Endocrinology and Metabolism : TEM·O DohanN Carrasco
Sep 11, 2004·Molecular and Cellular Endocrinology·Daniel Christophe

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