Cloning of a membrane-spanning protein with epidermal growth factor-like repeat motifs from adrenal glomerulosa cells

Endocrinology
S K HalderM Okamoto

Abstract

The three zones of adrenal cortex are thought to arise from a single multipotential stem cell, but the mechanisms underlying the zonal differentiation during embryonic development of adrenal cortex are poorly understood. Employing subtraction cloning strategy, we isolated three distinct clones that were specifically expressed in the rat glomerulosa zone. One clone, named zona glomerulosa specific clone, encoded a membrane-spanning protein with a signal peptide at the N-terminus, six epidermal growth factor-like repeat motifs, and a transmembrane domain near the C-terminus. It was identified as a rat homolog of preadipocyte factor-1 (Pref-1), a factor involved in maintaining the undifferentiated status of preadipocyte. Immunohistochemical studies confirmed the presence of Pref-1 protein in the glomerulosa zone. Detailed examination revealed that the zone is divided into two layers; the first is a few-cells-thick layer present underneath the capsule (expressing both Pref-1 protein and aldosterone synthase cytochrome P450), and the second layer is beneath the first (containing Pref-1 protein but not aldosterone synthase). Moreover, another cell layer was found beneath the second layer and above the fasciculata zone, whose cells co...Continue Reading

References

Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·Y NonakaT Omura
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T KawamotoH Imura
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A Jimenez-RuizC Alonso
May 31, 1990·Biochemical and Biophysical Research Communications·N MatsukawaM Okamoto
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J HelmanM A Israel
Feb 1, 1986·Annals of Internal Medicine·C A SteinE P Gelmann
Jan 1, 1974·Cell and Tissue Research·D Wassermann, M Wassermann
Dec 8, 1983·Nature·M JansenJ L Van den Brande
Sep 1, 1995·The Journal of Clinical Investigation·G AguileraB Sunar-Akbasak
Mar 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·T SunM Okamoto
Mar 24, 1995·Cell·C E LindsellG Weinmaster
Jan 2, 1995·Biochimica Et Biophysica Acta·W C BoonJ P Coghlan
Jun 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·J G LeHouxA Lefebvre
Jun 1, 1994·The Journal of Endocrinology·M M HoG P Vinson
Feb 12, 1993·Science·N LisitsynM Wigler
Jan 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·S VéronneauJ G LeHoux
Oct 24, 1996·Nature·T Gridley
Nov 25, 1996·Developmental Biology·C ShawberG Weinmaster

❮ Previous
Next ❯

Citations

Dec 22, 2011·BMC Molecular Biology·Samuel RiveroJosé J García-Ramírez
May 1, 2009·Endocrine Reviews·Alex C KimGary D Hammer
Jun 23, 2009·Molecular Endocrinology·Hei Sook Sul
Jul 18, 2012·Haematologica·Bahar Mirshekar-SyahkalKatrin Ottersbach
Aug 30, 2008·Histochemistry and Cell Biology·Takashi NakakuraShigeyasu Tanaka
Jan 24, 2012·Molecular and Cellular Endocrinology·Derek P Simon, Gary D Hammer
Oct 25, 2011·Molecular and Cellular Endocrinology·Ed LauferPeter King
Oct 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Hiroshi Takemori, Mitsuhiro Okamoto
Feb 17, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Eric Santoni-RugiuHanne Cathrine Bisgaard
Jan 18, 2005·Experimental Cell Research·Victoriano BaladrónJorge Laborda
May 12, 2004·Molecular and Cellular Endocrinology·G P Vinson
Jan 13, 2006·Biochemical and Biophysical Research Communications·T AltenbergerA Luger
Jun 15, 2007·The FEBS Journal·Hiroshi TakemoriMitsuhiro Okamoto
Nov 26, 2010·Molecular and Cellular Endocrinology·Leonardo GuastiPeter King
Mar 24, 2015·Frontiers in Endocrinology·Marjut PihlajokiDavid B Wilson
May 10, 2008·Journal of Molecular Biology·María-Luisa NuedaVictoriano Baladrón
May 19, 2016·Biochemical and Biophysical Research Communications·Donghee LeeYoung Woo Park
Sep 14, 2016·Molecular and Cellular Endocrinology·Emanuele PignattiDavid T Breault
Apr 14, 2010·Experimental Cell Research·Ditte C AndersenSøren P Sheikh
Oct 24, 2017·Journal of Cellular Physiology·Weifeng XuShanyong Zhang
Mar 27, 2004·Physiological Reviews·András Spät, László Hunyady
Aug 23, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stefan Jude SamulewiczEllen Heber-Katz
May 28, 2003·Microscopy Research and Technique·G P Vinson
Aug 18, 2009·Virchows Archiv : an International Journal of Pathology·Eszter TurányiPeter Nagy
Jun 24, 2005·American Journal of Physiology. Endocrinology and Metabolism·William B EnnenWilliam C Engeland
Oct 24, 2017·Endocrinology·Neta GotliebShamgar Ben-Eliyahu
Feb 17, 2007·Endocrinology·Damian G RomeroCelso E Gomez-Sanchez
Nov 30, 2019·Frontiers in Endocrinology·Katia MarinielloLeonardo Guasti
Nov 23, 2006·The Journal of Nutrition·Yuhui WangHei Sook Sul
Apr 8, 2017·Frontiers in Endocrinology·Antonio Marcondes LerarioGary Douglas Hammer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.