PMID: 9432002Feb 7, 1998Paper

Cloning of an unusual natriuretic peptide from the South American coral snake Micrurus corallinus

European Journal of Biochemistry
P L HoI Raw

Abstract

In the course of cloning abundant cDNAs from the South American coral snake Micrurus corallinus venom gland, we characterized a cDNA coding for a putative natriuretic peptide. All the natural natriuretic peptides described so far, possess a ring structure composed of 17 amino acids formed through an S-S bridge which is extended at the N-terminus by few to several amino acids and may be extended at the C-terminus, usually 4-7 amino acids. In contrast, the M. corallinus natriuretic peptide presents several distinct features: (a) the proform of the deduced natriuretic peptide displays an unusual C-terminus extension. This implies that the mature peptide has a long C-terminal tail or it is further extensively processed to result in the mature natriuretic peptide with the expected 4-7 amino-acid extension. (b) the deduced natriuretic peptide presents an unusual internal Cys within the ring structure. This raises the possibility of natriuretic peptides with a smaller ring structure. (c) the putative natriuretic peptide is flanked by two homologous peptides of unknown function. In addition, an analogous peptide was synthesized and assayed on perfused rat kidney, showing a dose-dependent response in urinary volume and sodium excretion....Continue Reading

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Citations

Apr 19, 2007·Heart Failure Reviews·Candace Y W Lee, John C Burnett
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Mirian A F Hayashi, Antonio C M Camargo
May 7, 2005·Toxicon : Official Journal of the International Society on Toxinology·Márcia Regina SoaresMarcelo Ribeiro Vasconcelos Diniz
Feb 27, 2001·Toxicon : Official Journal of the International Society on Toxinology·A R Prieto da SilvaJ S Oliveira
Oct 16, 2001·Toxicon : Official Journal of the International Society on Toxinology·A HavtH S Monteiro
Dec 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·Steven D Aird
Oct 16, 2003·Toxicon : Official Journal of the International Society on Toxinology·Ursula Castro de OliveiraPaulo Lee Ho
Mar 20, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·N Jorge da Silva, S D Aird
Sep 25, 2008·Nature Clinical Practice. Nephrology·Visith Sitprija
Aug 5, 1999·Kidney International·O LisyJ C Burnett
Mar 18, 2009·BMC Genomics·Luciana I LeãoInacio de L M Junqueira-de-Azevedo
Aug 2, 2011·Journal of Proteomics·Paula H C CiscottoAdriano M C Pimenta
Mar 31, 2011·Toxicon : Official Journal of the International Society on Toxinology·Cho Yeow Koh, R Manjunatha Kini
Mar 1, 2006·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Koji Inoue, Yoshio Takei
Feb 22, 2011·Toxicon : Official Journal of the International Society on Toxinology·Weiwei LeiYun Zhang
Nov 6, 2010·Toxicon : Official Journal of the International Society on Toxinology·Yong ZhangQiumin Lu
Oct 30, 2016·Toxicon : Official Journal of the International Society on Toxinology·Bruno LomonteJuan J Calvete
Jul 1, 2020·The American Journal of Tropical Medicine and Hygiene·Saptarshi BhattacharyaVineet Surana

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