PMID: 11913777Mar 27, 2002Paper

Cloning of bovine eukaryotic translation initiation factor 4E (eIF-4E) and its expression in the bovine mammary gland at different physiological stages

DNA Sequence : the Journal of DNA Sequencing and Mapping
E LongX Zhao

Abstract

Bovine eIF-4E cDNA was cloned and its expression in the bovine mammary gland at distinct physiological stages was investigated. Bovine eIF-4E cDNA and protein sequences are highly homologous to those from other mammals. Using Northern blot analysis, we did not detect eIF-4E expression in the prepubertal bovine mammary gland, whereas a low level of eIF-4E mRNA was observed in the mammary tissues of heifers during the third estrous cycle. The eIF-4E mRNA level was significantly higher in the lactating mammary gland compared to the mammary tissues obtained from heifers during the third estrous cycle. Alteration of eIF-4E expression in bovine mammary tissues during different physiological stages indicates the involvement of eIF-4E in mammary development. Elevated eIF-4E expression during lactation may be related to increased translation of certain mRNA or the acceleration of overall protein synthesis.

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Citations

Nov 28, 2007·BMC Systems Biology·Danielle G LemayJ Bruce German
Jun 24, 2011·Bioinformatics and Biology Insights·Massimo Bionaz, Juan J Loor
Nov 16, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey S ShenbergerAaron Barchowsky
Dec 25, 2008·Functional & Integrative Genomics·Karensa K MenziesKevin R Nicholas

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