Cloning of rat brain protein kinase C complementary DNA

FEBS Letters
Y OnoY Nishizuka

Abstract

Four peptides derived from rat brain protein kinase C were partially sequenced. Using synthetic oligonucleotides deduced from the amino acid sequences as probes, a clone of complementary DNA (cDNA) was isolated from a cDNA library prepared from the same tissue. The nucleotide sequence of this cDNA clone revealed the primary structure of the carboxyl-terminal region as having 224 amino acids, with significant sequence homology with cyclic AMP-dependent and cyclic GMP-dependent protein kinases.

References

Sep 16, 1976·Nature·N J Proudfoot, G G Brownlee
Mar 13, 1986·Biochemical and Biophysical Research Communications·U KikkawaY Nishizuka
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M D UhlerG S McKnight
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S ShojiK Titani
Feb 1, 1982·Molecular and Cellular Biology·H Okayama, P Berg
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D DiMaioT Maniatis
Feb 1, 1983·Molecular and Cellular Biology·H Okayama, P Berg

❮ Previous
Next ❯

Citations

Dec 1, 1996·Protein Science : a Publication of the Protein Society·E A Nalefski, J J Falke
Jan 1, 1991·Pharmacology & Therapeutics·S Stabel, P J Parker
Apr 7, 1992·Biochimica Et Biophysica Acta·R Zidovetzki, D S Lester
Jul 1, 1994·Molecular and Cellular Endocrinology·S Garcia-NavarroZ Naor
Jan 1, 1990·Neuroscience Letters·S ShimosawaH Hidaka
Oct 28, 1991·Neuroscience Letters·M Hietanen-PeltolaM Pelto-Huikko
Jan 1, 1991·Domestic Animal Endocrinology·J L Tilly, A L Johnson
Jan 1, 1989·Cellular Signalling·B E KempA R Means
Oct 31, 1988·Biochemical and Biophysical Research Communications·A FaragóA Spät
Jun 24, 2000·Biochimie·R R DuncanR H Chow
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S Jaken, S C Kiley
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D Mochly-RosenD E Koshland
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S K Hanks
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G M HouseyI B Weinstein
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Z NaorR Limor
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K HosodaY Nishizuka
Jun 10, 1988·Nucleic Acids Research·T KurokawaK Igarashi
Jun 1, 1989·European Journal of Biochemistry·R M Marais, P J Parker
Sep 1, 1993·Pharmacology & Therapeutics·D P Leader
Sep 11, 1987·Cell·T Hunter
Jul 1, 2006·Biochimica Et Biophysica Acta·Senena Corbalán-García, Juan C Gómez-Fernández
Jan 21, 2014·Biochimica Et Biophysica Acta·Senena Corbalan-Garcia, Juan C Gómez-Fernández
Mar 22, 1988·Biochemistry·S OhnoK Suzuki
Oct 30, 1986·Biochemical and Biophysical Research Communications·M WolfN Sahyoun
Jul 31, 1987·Biochemical and Biophysical Research Communications·T KunoC Tanaka
Dec 31, 1987·Biochemical and Biophysical Research Communications·F L HuangK P Huang
Jul 15, 1987·Biochemical and Biophysical Research Communications·P G McCaffreyY Nishizuka
Jan 10, 1998·The Journal of Biological Chemistry·J E JohnsonA C Newton
Mar 18, 2000·The Journal of Biological Chemistry·A Toker, A C Newton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.