Cloning of rat GADD45 gene and induction analysis following ionizing radiation in vivo

FEBS Letters
T YoshidaN Mori

Abstract

A gene encoded GADD45 was isolated from rat and revealed four exons along with a p53 binding consensus sequence and a putative AP-1 site in the third intron. This suggests that the rat GADD45 gene is also involved in the p53 signal pathway related to the G1 cell cycle checkpoint. The rat GADD45 mRNA was induced within 30 min in liver and increased as a function of gamma-irradiation. We found that mRNA expression differed substantially in a variety of tissues (brain, liver, kidney, and spleen). The finding of in vivo induction of GADD45 gene may provide insight into the role of GADD45 gene in DNA repair.

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Citations

Nov 9, 2000·European Journal of Pharmacology·T OkuraK Hiwada
Jan 1, 1997·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·S T HouJ P MacManus
Jan 8, 2000·Neurosurgery·M M O'Connor, M R Mayberg

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