PMID: 2498880Jun 1, 1989Paper

Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation

Proceedings of the National Academy of Sciences of the United States of America
W ReithB Mach

Abstract

The regulation of major histocompatibility complex class II gene expression is directly involved in the control of normal and abnormal immune responses. In humans, HLA-DR, -DQ, and -DP class II heterodimers are encoded by a family of alpha- and beta-chain genes clustered in the major histocompatibility complex. Their expression is developmentally controlled and normally restricted to certain cell types. This control is mediated by cis-acting sequences in class II promoters and by trans-acting regulatory factors. Several nuclear proteins bind to class II promoter sequences. In a form of hereditary immunodeficiency characterized by a defect in a trans-acting regulatory factor controlling class II gene transcription, we have observed that one of these nuclear factors (RF-X) does not bind to its target sequence (the class II X box). A cDNA encoding RF-X was isolated by screening a phage expression library with an X-box binding-site probe. The recombinant protein has the binding specificity of RF-X, including a characteristic gradient of affinity for the X boxes of HLA-DR, -DP, and -DQ promoters. RF-X mRNA is present in the regulatory mutants, indicating a defect in the synthesis of a functional form of the RF-X protein.

References

Dec 1, 1986·Immunological Reviews·G F BottazzoR Pujol-Borrell
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K MiwaJ L Strominger
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A DornD Mathis
Jun 1, 1988·The Journal of Experimental Medicine·W KochD Mathis
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M A BlanarR A Flavell
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M Sakurai, J L Strominger
Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·B MachC Ucla
Sep 11, 1987·Cell·A DornD Mathis
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B S PollaL H Glimcher
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P T MassaA Fontana
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P A ShermanJ P Ting
Jun 12, 1981·Science·B Benacerraf
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H SaitoS Tonegawa
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L A MatisR H Schwartz

❮ Previous
Next ❯

Citations

Apr 1, 1993·Molecular Biology Reports·S C Silver, S W Hunt
Jan 1, 1995·International Journal of Clinical & Laboratory Research·S Sartoris, R S Accolla
Jan 1, 1993·Immunologic Research·J P Ting
Sep 1, 1994·Pharmacology & Therapeutics·Y Ohmori, T A Hamilton
Jun 1, 1991·Research in Immunology·B M Peterlin
Feb 1, 1991·Current Opinion in Immunology·C J Kara, L H Glimcher
Aug 1, 1993·Current Opinion in Immunology·A Fischer
Nov 27, 1998·Human Immunology·P IndovinaM C Mazzilli
Jan 15, 1999·Insect Biochemistry and Molecular Biology·Z Shen, M Jacobs-Lorena
Aug 17, 1995·The New England Journal of Medicine·F S RosenR J Wedgwood
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C DoyleJ L Strominger
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J P CogswellJ P Ting
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Z YangJ L Strominger
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B Bénichou, J L Strominger
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S J OnoL H Glimcher
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M SugawaraJ L Strominger
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K L Wright, J P Ting
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R B PanekE N Benveniste
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C MaoG R Stark
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C F VolivaB M Peterlin
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·W ReithB Mach
Jan 1, 1991·The Journal of Experimental Medicine·L C AndersenB S Nepoom
Mar 25, 1991·Nucleic Acids Research·S L HasegawaJ M Boss
Feb 11, 1993·Nucleic Acids Research·M N OmbraJ Guardiola
Aug 5, 2008·BMC Evolutionary Biology·Syed AftabNansheng Chen
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·T SchollJ L Strominger
Jan 1, 1990·Immunologic Research·B M PeterlinS Tsang
Jan 1, 1996·Cancer Investigation·D V Kalvakolanu, E C Borden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.