PMID: 9165094Apr 25, 1997Paper

Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm)

Biochimica Et Biophysica Acta
R K BledsoeSusan M Hutson

Abstract

The rat and human mitochondrial branched chain aminotransferase (BCAT(m)) cDNAs have been isolated and shown to encode mature proteins of 41.2 and 41.3 kDa with presequences of 27 amino acids. When rat BCAT(m) is overexpressed in COS-1 cells, the protein exhibits BCAT activity and correct processing of the mitochondrial targeting sequence. Southern blot analysis of genomic DNA from a panel of rodent-human somatic cell hybrids revealed that the human BCAT(m) gene resides on chromosome 19 and the human cytosolic enzyme (BCAT(c)) gene on chromosome 12. Finally, the nomenclature BCAT1 for the cytosolic gene and BCAT2 for the mitochondrial BCAT gene is proposed.

References

Jan 18, 1989·Biochimica Et Biophysica Acta·F U HartlW Neupert
Jul 1, 1995·Protein Science : a Publication of the Protein Society·N V GrishinE J Goldsmith
Dec 22, 1995·The Journal of Biological Chemistry·S M HutsonP A Dawson

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Citations

Nov 18, 2014·Journal of Proteome Research·Cheryl F LichtiCarol L Nilsson
Apr 6, 2013·Journal of Applied Toxicology : JAT·Yoko NishimuraTakeki Uehara
Jun 2, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Yi-Hu ZhengQi-Yu Zhang
May 16, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dipsikha BiswasThomas Pulinilkunnil
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·A R TovarN Torres
Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Christopher J LynchThomas C Vary
Mar 23, 2017·Amino Acids·María M Adeva-AndanyCristina Sixto-Leal
Jul 3, 1998·The Journal of Nutrition·S DeSantiagoS M Hutson
Jan 4, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Diana AntunesDoron Rapaport
Aug 7, 2021·Frontiers in Physiology·Gagandeep MannOlasunkanmi A J Adegoke

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