PMID: 3517854May 1, 1986Paper

Cloning, sequence, and expression of bovine interleukin 2

Proceedings of the National Academy of Sciences of the United States of America
D P CerrettiP E Baker

Abstract

Interleukin 2 (IL-2) cDNA clones have been isolated from both human and murine sources. We report here the isolation of a cDNA clone encoding bovine IL-2. This was accomplished by screening a cDNA library constructed from lectin-stimulated bovine lymph node cells, using a human IL-2 probe. Bovine IL-2 is composed of 155 amino acids and has a predicted molecular weight of 19,555. Alignment of the amino acid sequence with human IL-2 indicates that mature bovine IL-2 is composed of 135 amino acids and has a predicted molecular weight of 15,452. It has an amino acid homology of 65% with human IL-2 and 50% with murine IL-2. Bovine IL-2 is unique among IL-2 homologs in that it has a single N-linked glycosylation site. Biologically active bovine IL-2 was synthesized in an Escherichia coli expression system.

References

Jul 14, 1977·Nature·S Gillis, K A Smith
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T YokotaK Arai
Sep 1, 1984·Veterinary Immunology and Immunopathology·M Miller-Edge, G A Splitter
Jul 1, 1980·Analytical Biochemistry·B R OakleyN R Morris
Jul 1, 1982·Veterinary Immunology and Immunopathology·P E Baker, K F Knoblock
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S C ClarkS Oroszlan
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G JayE Jay
Jul 11, 1983·Nucleic Acids Research·R DevosW Fiers
Sep 30, 1983·Biochemical and Biophysical Research Communications·S MaedaK Onoue
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R J RobbV Chowdhry
Jul 11, 1984·Nucleic Acids Research·M E Watson
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M D BigginG F Hong
Jun 1, 1983·Transplantation·S A RosenbergS Schwarz
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N J HolbrookG R Crabtree

❮ Previous
Next ❯

Citations

Aug 29, 1996·Mechanisms of Ageing and Development·M A Pahlavani, A Richardson
Feb 1, 1993·Molecular Immunology·J Lederer, C Czuprynski
Dec 1, 1987·Veterinary Immunology and Immunopathology·G V Alm
Dec 1, 1987·Veterinary Immunology and Immunopathology·N S MagnusonR Reeves
Dec 1, 1987·Veterinary Immunology and Immunopathology·P E Baker
Jul 1, 1989·Veterinary Immunology and Immunopathology·S R LeongP W Gray
Nov 30, 1989·Veterinary Immunology and Immunopathology·P G ReddyP E Baker
May 1, 1992·Veterinary Immunology and Immunopathology·P M TorreS P Oliver
Jun 1, 1993·Veterinary Immunology and Immunopathology·D N ReddyF Blecha
Dec 1, 1993·Veterinary Immunology and Immunopathology·E V Vandergrifft, D W Horohov
Jun 13, 1991·Biochimica Et Biophysica Acta·J C GoodallL Hall
Dec 16, 1992·Biochimica Et Biophysica Acta·Y MinamiT Taniguchi
Jul 4, 1995·Gene·D W KnappO M Andrisani
Apr 29, 2004·Veterinary Immunology and Immunopathology·Raadan OdbilegMisao Onuma
Jan 5, 2002·Veterinary Immunology and Immunopathology·Ann Marie WhiteCynthia L Baldwin
May 1, 1997·Veterinary Immunology and Immunopathology·R G KeefeJ L Stott
Oct 9, 1998·Veterinary Immunology and Immunopathology·L A van PinxterenD R Snodgrass
Oct 16, 1999·Veterinary Immunology and Immunopathology·L A van PinxterenD R Snodgrass
Jun 27, 2013·Animal Health Research Reviews·Randall L Levings, James A Roth
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T Ohta
Jan 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B J RuefW C Brown
Oct 11, 1990·Nucleic Acids Research·J C GoodallL Hall
Jul 21, 1998·Annals of the New York Academy of Sciences·W L GoffC W Cluff
May 1, 1993·Equine Veterinary Journal·A S TavernorG W Butcher
Sep 29, 2010·Prikladnaia biokhimiia i mikrobiologiia·M V PadkinaE V Sambuk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved