PMID: 8995762Dec 1, 1996Paper

Cloning, sequencing, and chromosomal localization of two tandemly arranged human pseudogenes for the proliferating cell nuclear antigen (PCNA)

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Y TaniguchiH Inoko

Abstract

We have characterized a human genomic clone carrying two pseudogenes for the proliferating cell nuclear antigen (PCNA), which were tandemly arranged on human Chromosome (Chr) 4. One is a processed pseudogene that showed a 73% nucleotide homology to the human PCNA cDNA and possessed none of the introns existing in the functional PCNA gene. This pseudogene presumably arose by reverse transcription of a PCNA mRNA followed by integration of the cDNA into the genome. The other is a 5' and 3' truncated pseudogene that showed a nucleotide homology to a 3' region of the exon 4 and to a 5' region of the exon 5 of the PCNA gene and did not have the intronic sequence between the exons 4 and 5. Both pseudogenes had the same nucleotide deletion as compared with the human functional PCNA gene. A phylogenetic analysis of PCNA gene family, including the functional PCNA gene and another PCNA pseudogene located on a different chromosome, revealed that the truncated pseudogene exhibits the closest evolutionary relationship with the processed pseudogene, suggesting that the truncated pseudogene was generated by duplication of the processed pseudogene after translocation to Chr 4. Furthermore, fluorescence in situ hybridization revealed that these ...Continue Reading

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Citations

Jul 13, 2000·Brain Research. Molecular Brain Research·H Ino, T Chiba
Feb 9, 2012·BMC Research Notes·Ivaylo Stoimenov, Anne Lagerqvist
Jun 2, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hans-J WelkoborskyMike L Hinni
Apr 27, 2013·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Wen LiXiu-Jie Wang
Dec 12, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Irene SchillerAndreas Pospischil
Feb 29, 2000·FEBS Letters·A J MighellA F Markham

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