Cloning, sequencing, and polymorphism analysis of novel classical MHC class I alleles in northern pig-tailed macaques (Macaca leonina)

Immunogenetics
Xiao-Dong LianYongtang Zheng

Abstract

The northern pig-tailed macaque (Macaca leonina) has been confirmed to be an independent species from the pig-tailed macaque group of Old World monkey. We have previously reported that the northern pig-tailed macaques were also susceptible to HIV-1. Here, to make this animal a potential HIV/AIDS model and to discover the mechanism of virus control, we attempted to assess the role of major histocompatibility complex (MHC) class I-restricted immune responses to HIV-1 infection, which was associated with viral replication and disease progression. As an initial step, we first cloned and characterized the classical MHC class I gene of northern pig-tailed macaques. In this study, we identified 39 MHC class I alleles including 17 MHC-A and 22 MHC-B alleles. Out of these identified alleles, 30 were novel and 9 were identical to alleles previously reported from other macaque species. The MHC-A and MHC-B loci were both duplicates as rhesus macaques and southern pig-tailed macaques. In addition, we also detected the patterns of positive selection in northern pig-tailed macaques and revealed the existence of balance selection with 20 positive selection sites in the peptide binding region. The analysis of B and F peptide binding pockets in ...Continue Reading

References

Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·N LeeD E Geraghty
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bianca R MothéAlessandro Sette
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernard A P LafontMalcolm A Martin
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph D MillerPeter E Jensen
Jun 3, 2004·Genome Research·Gavin E CrooksSteven E Brenner
Aug 4, 2004·Genome Research·Riza Daza-VamentaDaniel E Geraghty
Nov 11, 2006·Immunogenetics·Bridget F PrattMiranda Z Smith
May 8, 2007·Molecular Biology and Evolution·Ziheng Yang
Dec 22, 2007·Immunogenetics·Julie A KarlDavid H O'Connor
Nov 8, 2008·Acta Biochimica Et Biophysica Sinica·Dongyun OuyangXianhui He
Sep 2, 2011·Immunogenetics·Yusuke SaitoAkinori Kimura
Jul 24, 2012·Primates; Journal of Primatology·Suchinda MalaivijitnondYuzuru Hamada
Nov 28, 2012·Nucleic Acids Research·James RobinsonSteven G E Marsh
Apr 11, 2013·Zoological Research·Ai-Hua LeiYong-Tang Zheng
Jun 19, 2013·Immunological Reviews·Maureen P Martin, Mary Carrington
Sep 21, 2013·Immunogenetics·Xiang YanZhaozeng Sun
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Aug 19, 2014·Immunogenetics·Julie A KarlDavid H O'Connor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.