Cloning, sequencing and structural analysis of 976 base pairs of the promoter sequence for the rat lipoprotein lipase gene. Comparison with the mouse and human sequences

Gene
L BeyF Galibert

Abstract

We cloned and sequenced the -976bp promoter of the rat lipoprotein lipase LPL gene. The sequence was compared with the mouse and human sequences. The homology between the rat and mouse LPL nucleotide sequences was not quite as strong in the promoter sequence as in the coding sequence. Among the 976nt promoter there were 118 divergences, i.e. 11.8%, compared to only 5.6% for the LPL coding region. However, within the 200nt immediately 5' to the transcriptional start site (proximal promoter), the divergence was only 4%. New potential cis-elements (such as CACCC, GATA, GC and GA boxes, IRS, Krox, MEF 2, E-box, CCArGG and 1/2 VDRE) were identified in the rat, mouse or human LPL gene.

References

Nov 16, 1992·Gene·D BraultM Lavau
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M B DemayH M Kronenberg
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T G KirchgessnerA Andalibi
May 16, 1989·Biochemistry·S S Deeb, R L Peng
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C R HuntB M Spiegelman
Jul 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A RaisonnierF Galibert
Oct 1, 1996·Physiological Reviews·R M O'Brien, D K Granner

❮ Previous
Next ❯

Citations

Dec 21, 2000·Current Atherosclerosis Reports·S Gehrisch
Dec 10, 1999·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M InoueY Ogihara
Dec 27, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Alfonso Saera-VilaJaume Pérez-Sánchez
Feb 7, 2006·General and Comparative Endocrinology·Amaya AlbalatIsabel Navarro
Mar 23, 2017·Journal of Developmental Origins of Health and Disease·J K ClealL R Green
Aug 10, 2010·Journal of Lipid Research·Su-Jin KimChristopher H S McIntosh
Nov 28, 2002·Journal of Lipid Research·Martin MerkelIra J Goldberg
May 9, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Julien DelezieEtienne Challet
Sep 28, 2002·Current Opinion in Lipidology·Karina Preiss-LandlRudolf Zechner
Apr 9, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aaron P RussellPatrick Schrauwen
Mar 30, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Hiromi OkuXu Fang Liang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.