Cloning the chicken leptin gene

Gene
M TaouisJ Simon

Abstract

Chicken is characterized by a relative insulin resistance and a physiological hyperglycemia (2g/L) and is also subjected to fattening. Fat deposits in chicken, as in mammals, are regulated by environmental and genetic factors. In mammals, leptin, an adipose cell-specific secreted protein has been characterized that is encoded by ob gene. Leptin regulates satiety through hypothalamic specific receptors, energy balance, energy efficiency and contributes to adaptation to starvation. The leptin gene has been characterized in various mammalian species, and the cloning and sequencing of the chicken leptin gene (ob gene) are reported. Using RT-PCR and primers flanking the coding region of the leptin gene selected from known mammalian sequences, we have successfully amplified a 600-bp fragment from chicken liver and adipose tissue total ARNs. The amplified fragment exhibits a similar size to that of the coding region of the mammalian leptin gene. The sequences of the coding region of chicken liver and adipose tissue are identical and presented 97%, 96% and 83% similarity to the mouse, rat and human sequences, respectively. Finally, this is the first report showing that leptin gene expression in chicken is not exclusively localized in a...Continue Reading

References

Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Jul 28, 1995·Science·M A PelleymounterF Collins
Oct 1, 1993·Molecular and Cellular Endocrinology·M TaouisJ Simon
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·G ChenR H Unger
Nov 15, 1996·Science·S I TaylorM Reitman
May 8, 1997·Nature·F ZhangR W Schevitz

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Citations

May 8, 2000·The Journal of Experimental Zoology·R M JohnsonR L Londraville
Sep 11, 1999·General and Comparative Endocrinology·M Friedman-EinatP J Sharp
Nov 13, 2001·General and Comparative Endocrinology·C DoyonT W Moon
May 24, 2005·Brain Research·Sami DridiJohan Buyse
May 26, 2004·Domestic Animal Endocrinology·S CassyM Taouis
Jun 9, 2005·Domestic Animal Endocrinology·Sami DridiMohammed Taouis
Oct 1, 2013·General and Comparative Endocrinology·Shan HeYa-Xiong Tao
Oct 24, 2002·General and Comparative Endocrinology·Francisco J MuruzábalMaría A Burrell
Nov 1, 2002·General and Comparative Endocrinology·Richard L Londraville, Charles S Duvall
Mar 7, 2003·General and Comparative Endocrinology·Mare LõhmusBengt Silverin
Jun 28, 2000·Physiology & Behavior·D M DenbowC Ashwell
Sep 16, 2000·Journal of Biochemical and Biophysical Methods·M P RichardsJ P McMurtry
Apr 13, 2000·Biochimica Et Biophysica Acta·T OhkuboK Nakashima
Jun 16, 2000·Molecular and Cellular Endocrinology·G HorevM Friedman-Einat
May 4, 2000·Domestic Animal Endocrinology·S DridiM Taouis
Mar 2, 2002·Domestic Animal Endocrinology·M TaouisA Gertler
Dec 23, 1998·Domestic Animal Endocrinology·K L Houseknecht, C P Portocarrero
Sep 14, 1999·Domestic Animal Endocrinology·C M AshwellR Vasilatos-Younken
May 5, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S P Reidy, J Weber
Mar 14, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J Jensen
Dec 10, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Mark P Richards, Stephen M Poch
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·A R G Wylie
Mar 2, 1999·Animal Genetics·S Lowden, R Drinkwater
Jun 17, 2011·Neuroendocrinology·Robert J DenverGraham C Boorse
Jun 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Erica J Crespi, Robert J Denver
Mar 22, 2014·Reproductive Biology and Endocrinology : RB&E·Ming M LeiZhen D Shi
Jul 13, 2014·Molecular Biology and Evolution·Nataša DakovićPhilippe Monget
Nov 22, 2000·Animal Genetics·F PitelA Vignal
Sep 24, 2011·Integrative and Comparative Biology·Susannah S FrenchGregory E Demas
May 9, 2012·Hormones and Behavior·Elizabeth D CarltonSusannah S French
Jan 6, 2016·The Indian Journal of Surgery·Sevgi Buyukbese SarsuCahit Bağcı
Oct 27, 2009·General and Comparative Endocrinology·Frédérique PitelPhilippe Monget
Oct 28, 2009·General and Comparative Endocrinology·Guan-Gui LiKaaseng Lai
Sep 30, 2009·Domestic Animal Endocrinology·E OnsS Dridi
Sep 8, 2015·General and Comparative Endocrinology·Dandan WangXiaojun Liu
Jan 15, 2008·General and Comparative Endocrinology·M YacobovitzA Gertler
Jan 11, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Xiaojun Liu, Peter J Sharp

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