Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021.

The Journal of Antibiotics
Takahito OuchiSatoshi Ōmura

Abstract

Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 µM.

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Citations

Oct 22, 2020·Journal of Fungi·Peipei HanLigang Zhou
Jan 16, 2021·The Journal of Antibiotics·Aki IshiyamaMasato Iwatsuki
Mar 25, 2021·Applied Microbiology and Biotechnology·Jinyu ZhangWen-Bing Yin

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Datasets Mentioned

BETA
MH871675
LC523632

Methods Mentioned

BETA
column chromatography
NMR
acylation

Software Mentioned

BLASTN
Lasergene
SeqMan Pro

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