Clopenthixol decanoate in schizophrenia

Current Medical Research and Opinion
M W Carney, P Rutherford

Abstract

Clopenthixol decanoate was given to 20 chronic schizophrenic patients for 11 months in doses ranging from 100 mg initially up to 1000 mg 3-weekly subsequently, according to clinical response and the occurrence of adverse effects. A further 3 patients received the depot injections for periods of 6 to 9 months. Improvement in individual symptoms was rated on a 4-point scale. Unwanted effects were recorded on a checklist and routine biochemical and haematological tests were carried out at the beginning and end of the treatment period. There were highly significant improvements in the mean overall symptom score and in the 5 single symptom scores (hallucinations, delusions, depression, aggressive behaviour and non-aggressive behaviour disturbance). The 2 'negative' symptoms of apathy and social withdrawal showed improvement up to 16 weeks but not at 11 months. The incidence of depression was less at the end of the study than at the time fo entry. Three patients stopped the drug after the sixth month because of extrapyramidal symptoms (2) or drowsiness (1). Three others developed severe extra-pyramidal side-effects. Unwanted effects, though recorded in 70% of patients--drowsiness and extrapyramidal symptoms were the commonest--were f...Continue Reading

References

Nov 1, 1976·The British Journal of Psychiatry : the Journal of Mental Science·M W Carney, B F Sheffield
Jan 1, 1973·Current Medical Research and Opinion·M W Carney, B F Sheffield
Sep 6, 1969·British Medical Journal·R De Alarcon, M W Carney
Jan 12, 1980·British Medical Journal·T J Crow
Jan 1, 1980·Acta Psychiatrica Scandinavica. Supplementum·U G AhlforsJ Remvig

❮ Previous
Next ❯

Citations

Dec 1, 2001·Forensic Science International : Synergy·M KollroserC Schober
Sep 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·T J Mlele, Y V Wiley
Jul 1, 1986·Journal of Neurosurgery·R F SpetzlerP A Raudzens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here